| アブストラクト | BACKGROUND: Epidemiological and laboratory studies suggest that beta-blockers may reduce cancer progression in various cancer sites. The aim of this study was to conduct the first epidemiological investigation of the effect of post-diagnostic beta-blocker usage on colorectal cancer-specific mortality in a large population-based colorectal cancer patient cohort. PATIENTS AND METHODS: A nested case-control analysis was conducted within a cohort of 4794 colorectal cancer patients diagnosed between 1998 and 2007. Patients were identified from the UK Clinical Practice Research Datalink and confirmed using cancer registry data. Patients with a colorectal cancer- specific death (data from the Office of National Statistics death registration system) were matched to five controls. Conditional logistic regression was applied to calculate odds ratios (OR) and 95% confidence intervals (95% CIs) according to beta-blocker usage (data from GP-prescribing records). RESULTS: Post-diagnostic beta-blocker use was identified in 21.4% of 1559 colorectal cancer-specific deaths and 23.7% of their 7531 matched controls, with little evidence of an association (OR = 0.89 95% CI 0.78-1.02). Similar associations were found when analysing drug frequency, beta-blocker type or specific drugs such as propranolol. There was some evidence of a weak reduction in all-cause mortality in beta-blocker users (adjusted OR = 0.88; 95% CI 0.77-1.00; P = 0.04) which was in part due to the marked effect of atenolol on cardiovascular mortality (adjusted OR = 0.62; 95% CI 0.40-0.97; P = 0.04). CONCLUSIONS: In this novel, large UK population-based cohort of colorectal cancer patients, there was no evidence of an association between post-diagnostic beta-blocker use and colorectal cancer-specific mortality. CLINICAL TRIALS NUMBER: NCT00888797. |
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| ジャーナル名 | Annals of oncology : official journal of the European Society for Medical Oncology |
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| 投稿日 | 2013/9/21 |
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| 投稿者 | Hicks, B M; Murray, L J; Powe, D G; Hughes, C M; Cardwell, C R |
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| 組織名 | Centre for Public Health, Queen's University Belfast, Belfast, Northern, Ireland. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/24050955/ |
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