| アブストラクト | AIMS: To investigate the statistical association between hypoglycaemia and beta-blocker use and to define what patient and drug characteristics could potentially increase the risk for its occurrence. METHODS: We investigated the relationship between pharmacological parameters of beta-blockers and the occurrence of hypoglycaemia by conducting a case/non case analysis using the Food and Drug Administration Adverse Event Reporting System database. Pharmacological properties that could represent a predictive factor for hypoglycaemia were analysed through a multilinear binary logistic regression (null hypothesis rejected for values of P < .05). We also performed a systematic review of clinical studies on this association. RESULTS: Of 83 954 selected reports, 1465 cases (1.75%) of hypoglycaemia were identified. The association was found statistically significant for nadolol (reporting odds ratio [95% confidence interval]: 6.98 [5.40-9.03]), celiprolol (2.35 [1.35-4.10]), propranolol (2.14 [1.87-2.46]) and bisoprolol (1.42 [1.25-1.61]). Paediatric cases (n = 310) showed a positive association with hypoglycaemia for long half-life drugs (odds ratio [95% confidence interval]: 2.232 [1.398-3.563]) and a negative association for beta1-selectivity (0.644 [0.414-0.999]). Seven papers were included in the systematic review. Because of great heterogeneity in study design and demographics, hypoglycaemia incidence rates varied greatly among studies, occurring in 1.73% of the cases for propranolol treatment (n total participants = 575), 6.6% for atenolol (n = 30) and 10% for carvedilol (n = 20). CONCLUSION: Nadolol appears to be the beta-blocker significantly most associated with hypoglycaemia and children represent the most susceptible sample. Furthermore, long half-life and nonselective beta-blockers seem to increase the risk for its occurrence. |
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| ジャーナル名 | British journal of clinical pharmacology |
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| Pubmed追加日 | 2021/1/29 |
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| 投稿者 | Carnovale, Carla; Gringeri, Michele; Battini, Vera; Mosini, Giulia; Invernizzi, Elena; Mazhar, Faizan; Bergamaschi, Francesco; Fumagalli, Mara; Zuccotti, Gianvincenzo; Clementi, Emilio; Radice, Sonia; Fabiano, Valentina |
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| 組織名 | Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences L.;Sacco, "Luigi Sacco" University Hospital, Universita di Milano, 20157, Italy.;Department of Pediatrics, V. Buzzi Children's Hospital, ASST;Fatebenefratelli-Sacco, Universita di Milano, via Castelvetro, 32, Milan, 20154,;Italy.;Scientific institute IRCCS E. Medea, Bosisio Parini, LC, 23892, Italy. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/33506522/ |
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