| アブストラクト | BACKGROUND: Empirical evidence to support an association between biodiversity and childhood asthma remains limited, and the contributions of specific taxonomic groups have been poorly understood. This nationwide, retrospective cohort study aimed to evaluate the associations between a wide range of biodiversity indices during pre-, peri-, and post-natal periods and childhood persistent asthma. METHODS: We included child-mother dyads between January 2005 and January 2017 from the Japan Medical Data Center database. Species richness, net relatedness index (genetic diversity), and land-use types were defined based on the municipalities in which the children resided during each exposure period. The primary outcome was persistent asthma in children aged 4-5 years. Modified Poisson regression models were used to evaluate the association between the biodiversity indices and childhood persistent asthma. Results were adjusted for confounders and predictors of asthma, including infant sex, cesarean section delivery, parental history of asthma, particulate matter </=2.5 microm in aerodynamic diameter, nitrogen dioxide, population density, metropolitan area status, municipality-level area deprivation index, and prefectural-level smoking prevalence. RESULTS: A total of 109,233 child-mother dyads were included; 34.7% of the children had persistent asthma at 4-5 years of age. Greater species and genetic diversity of freshwater fish, along with stagnant water areas, were consistently associated with a 2-5% lower risk of childhood asthma. CONCLUSIONS: Biodiversity during early life was heterogeneously associated with childhood asthma. These findings suggest that conserving freshwater fish species and their habitats may contribute to asthma prevention in children. |
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| ジャーナル名 | Environmental epidemiology (Philadelphia, Pa.) |
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| Pubmed追加日 | 2025/10/16 |
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| 投稿者 | Shiroshita, Akihiro; Kataoka, Yuki; Wang, Qianzhi; Kajita, Naoki; Anan, Keisuke; Tamaki, Shingo; Ikari, Shogo; Kubota, Yasuhiro; Yajima, Nobuyuki |
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| 組織名 | Division of Rheumatology, Department of Medicine, Showa University School of;Medicine, Tokyo, Japan.;Scientific Research Works Peer Support Group (SRWS-PSG), Osaka, Japan.;Division of Epidemiology, Department of Medicine, Vanderbilt University School of;Medicine, Nashville, Tennessee.;Department of Internal Medicine, Kyoto Min-iren Asukai Hospital, Kyoto, Japan.;Department of Healthcare Epidemiology, Kyoto University Graduate School of;Medicine, School of Public Health, Kyoto, Japan.;Psychosomatic Medicine, St Luke's International Hospital, Tokyo, Japan.;Department of Allergy, Tokyo Metropolitan Children's Medical Center, Tokyo,;Japan.;Division of Respiratory Medicine, Saiseikai Kumamoto Hospital, Kumamoto, Japan.;Think Nature Inc., Okinawa, Japan.;Faculty of Science, University of the Ryukyus, Okinawa, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41098378/ |
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