| アブストラクト | BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterised by chronic fibrosis, and acute exacerbation of IPF (AE-IPF) is the leading cause of death in patients with IPF. Data on the association between the body mass index (BMI) and prognosis of AE-IPF are lacking. This study was performed to evaluate the association between BMI and in-hospital mortality in patients who developed AE-IPF using a national inpatient database. METHODS: Using the Japanese Diagnosis Procedure Combination database, we retrospectively collected data of inpatients with AE-IPF from 1 July, 2010 to 31 March, 2018. We performed a multivariable logistic regression analysis to evaluate the association between all-cause in-hospital mortality and BMI, categorised as underweight (<18.5 kg.m(-2)), low-normal weight (18.5-22.9 kg.m(-2)), high-normal weight (23.0-24.9 kg.m(-2)), overweight (25.0-29.9 kg.m(-2)) and obese (>/=30.0 kg.m(-2)). RESULTS: In total, 14 783 patients were eligible for this study. The in-hospital mortality rate was 59.0%, 55.0%, 53.8%, 54.8% and 46.0% in the underweight, low-normal weight, high-normal weight, overweight and obese groups, respectively. Underweight patients had a significantly higher mortality rate (OR 1.25, 95% CI 1.10-1.42) and obese patients had a significantly lower mortality rate (OR 0.71, 95% CI 0.54-0.94) than low-normal weight patients. CONCLUSION: Among patients with AE-IPF, the underweight group had higher mortality and the obese group had lower mortality. |
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| 投稿日 | 2021/7/2 |
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| 投稿者 | Awano, Nobuyasu; Jo, Taisuke; Yasunaga, Hideo; Inomata, Minoru; Kuse, Naoyuki; Tone, Mari; Morita, Kojiro; Matsui, Hiroki; Fushimi, Kiyohide; Nagase, Takahide; Izumo, Takehiro |
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| ジャーナル名 | ERJ open research |
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| 組織名 | Dept of Respiratory Medicine, Japanese Red Cross Medical Center, Tokyo, Japan.;Dept of Health Services Research, Graduate School of Medicine, The University of;Tokyo, Tokyo, Japan.;Dept of Respiratory Medicine, Graduate School of Medicine, The University of;Dept of Clinical Epidemiology and Health Economics, School of Public Health, The;University of Tokyo, Tokyo, Japan.;Dept of Health Services Research, Faculty of Medicine, University of Tsukuba,;Ibaraki, Japan.;Dept of Health Policy and Informatics, Tokyo Medical and Dental University;Graduate School of Medicine, Tokyo, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/34195254/ |
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