Body mass index and weight change are associated with mortality in chronic kidney disease: A retrospective cohort study using a Japanese medical claims database.

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Body mass index and weight change are associated with mortality in chronic kidney disease: A retrospective cohort study using a Japanese medical claims database.

Body mass index and weight change are associated with mortality in chronic kidney disease: A retrospective cohort study using a Japanese medical claims database.

アブストラクト	OBJECTIVES: This study aimed to investigate body mass index (BMI) and rate of weight change associated with adverse outcomes in Asian patients with chronic kidney disease. METHODS: A retrospective cohort study was performed between April 2014 and June 2022 using the administrative claims database compiled by the Japan Medical Data Center. Patients were defined as individuals with comorbidities with chronic kidney disease stages 3 to 5 on admission and were aged >/=40 y with BMI at admission and BMI information from a previous admission 3 to 12 mo earlier. Restricted cubic spline analysis and thin-plate smoothed spline analysis were performed. RESULTS: A total of 10 802 individuals were analyzed. The mean age was 74.6 +/- 11.3 y, number of men was 7175 (66.4%), and 2115 (19.6%) deaths were recorded. Smoothed splines for BMI found that low BMI was associated with high hazard ratio (HR) (BMI = 18.5 kg/m(2); HR = 1.3 [1.2-1.4]). Smoothed splines of weight change found higher HR with increasing rate of weight change for both weight gain and loss (weight change rate = -10%; HR = 1.4 [1.3-1.5]; weight change rate = 10%; HR = 1.2 [1.1-1.3]). In thin-plate smoothed spline analysis, the U-curve had a higher odds ratio as BMI decreased in patients with or without dialysis and as the degree of weight change increased. CONCLUSIONS: We found trends in BMI and rate of weight change associated with mortality in Asian patients with chronic kidney disease.
ジャーナル名	Nutrition (Burbank, Los Angeles County, Calif.)
Pubmed追加日	2023/8/7
投稿者	Ishida, Yuria; Maeda, Keisuke; Murotani, Kenta; Shimizu, Akio; Ueshima, Junko; Nagano, Ayano; Sonoi, Norihiro; Inoue, Tatsuro; Mori, Naoharu
組織名	Department of Nutrition, Aichi Medical University Hospital, Nagakute, Japan;;Department of Palliative and Supportive Medicine, Graduate School of Medicine,;Aichi Medical University, Nagakute, Japan.;Aichi Medical University, Nagakute, Japan; Nutritional Therapy Support Center,;Aichi Medical University Hospital, Nagakute, Japan; Department of Geriatric;Medicine, Hospital, National Center for Geriatrics and Gerontology, Obu, Japan.;Electronic address: kskmaeda1701@gmail.com.;Biostatistics Center, Kurume University, Kurume, Japan.;Aichi Medical University, Nagakute, Japan; Department of Health Science, Faculty;of Health and Human Development, The University of Nagano, Nagano, Japan.;Aichi Medical University, Nagakute, Japan; Department of Nutritional Service, NTT;Medical Center Tokyo, Shinagawa, Tokyo, Japan.;Aichi Medical University, Nagakute, Japan; Department of Nursing, Nishinomiya;Kyoritsu Neurosurgical Hospital, Nishinomiya Japan.;Center for Education in Medicine and Health Sciences, Graduate School of;Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama,;Japan.;Department of Physical Therapy, Niigata University of Health and Welfare,;Niigata, Japan.;Aichi Medical University Hospital, Nagakute, Japan.
Pubmed リンク	https://www.ncbi.nlm.nih.gov/pubmed/37544191/