| アブストラクト | BACKGROUND: Body mass index (BMI) of patients with ischemic stroke (IS) has been associated with prognosis and disability in studies in the United States. Although the Asian population is leaner, the optimal BMI for stroke-related disability remains unknown. OBJECTIVES: To clarify the association between BMI and disability in patients with IS from a national database in Japan. METHODS: The present study included 522,421 patients with IS identified in the JROAD-DPC database from April 2016 to March 2020. We used the WHO classification of BMI, which divides Asia-Pacific patients into five groups, to categorize BMI and the modified Rankin Scale (mRS) to assess stroke-related disability at admission and discharge. After multiple imputation for missing values, we conducted a multiple mixed-effect logistic regression analysis for poor mRS score (>2) in September 2023. In addition, we created a restricted cubic spline model between the odds ratio (OR) for poor mRS and BMI. RESULTS: The mRS score worsened during hospitalization in 60.1% of the patients with IS, and 45.7% had a poor mRS score at discharge. Overweight patients had the lowest OR of having a poor mRS score (OR: 0.898, 95% confidence interval: 0.895-0.902). The spline curve for the OR for poor mRS score was U-shaped with a BMI of 24.7 kg/m(2)as the apex value. CONCLUSION: The present study revealed a U-shaped relationship between BMI and stroke-related disability, with overweight patients having the lowest OR for disability at discharge. |
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| ジャーナル名 | Topics in stroke rehabilitation |
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| Pubmed追加日 | 2024/10/22 |
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| 投稿者 | Kanejima, Yuji; Ogawa, Masato; Ishihara, Kodai; Yoshida, Naofumi; Nakai, Michikazu; Kanaoka, Koshiro; Sumita, Yoko; Emoto, Takuo; Sakai, Yoshitada; Iwanaga, Yoshitaka; Miyamoto, Yoshihiro; Yamashita, Tomoya; Hirata, Kenichi; Izawa, Kazuhiro P |
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| 組織名 | Department of Public Health, Graduate School of Health Sciences, Kobe University,;Hyogo, Japan.;Department of Rehabilitation, Kobe City Medical Center General Hospital, Hyogo,;Japan.;Department of Rehabilitation Science, Osaka Health Science University, Osaka,;Department of Physical Therapy, Faculty of Nursing and Rehabilitation, Konan;Women's University, Hyogo, Japan.;Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe;University Graduate School of Medicine, Hyogo, Japan.;Clinical Research Support Center, University of Miyazaki Hospital, Miyazaki,;Department of Medical and Health Information Management, National Cerebral and;Cardiovascular Center, Osaka, Japan.;Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine,;Department of Advanced Medical and Pharmaceutical Sciences, Kobe University;Graduate School of Science, Technology and Innovation, Hyogo, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39436809/ |
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