| アブストラクト | BACKGROUND: Bone fractures in children represent a source of significant disability and morbidity. Are children with autistic spectrum disorder (ASD) at an altered risk of fractures compared with typically developing children? METHODS: Using the General Practice Research Database, the authors assessed the prevalence of fractures in boys with ASD diagnosed between 2 and 8 years. A cross-sectional design was used to compare the prevalence of fractures among children with ASD and age-matched controls, conditional logistic regression to explore the relative risk of having a fracture in association with diagnosed ASD. RESULTS: The study population comprised 3,219 boys with a first-time diagnosis of ASD and 12,265 matched controls. ASD was associated with a significantly decreased risk of developing a fracture at any time in childhood (odds ratio [OR], 0.68, 95% confidence interval [CI], 0.59-0.77, p < .0001). The relative risk estimates were lower for the time period after ASD diagnosis (OR, 0.56, 95% CI, 0.48-0.66, p < .0001) but were not different for the time period before ASD diagnosis (OR, 0.96, 95% CI, 0.78-1.18, p = .6866). Adjusting for use of different drugs did not change the estimates. CONCLUSION: The relative risk of experiencing a fracture at any time in childhood is lower for boys with ASD compared with healthy boys. |
|---|
| ジャーナル名 | Journal of developmental and behavioral pediatrics : JDBP |
|---|
| Pubmed追加日 | 2014/7/10 |
|---|
| 投稿者 | Furlano, Raoul I; Bloechliger, Marlene; Jick, Hershel; Meier, Christoph R |
|---|
| 組織名 | *Department of Gastroenterology and Nutrition, University Children's Hospital;(UKBB), Basel, Switzerland; daggerBasel Pharmacoepidemiology Unit, Division of;Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences,;University of Basel, Basel, Switzerland; double daggerBoston Collaborative Drug;Surveillance Program, Boston University School of Public Health, Lexington, MA;;and section signHospital Pharmacy, University Hospital Basel, Basel, Switzerland. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/25007057/ |
|---|
