| アブストラクト | BACKGROUND: GLP-1 receptor agonists carry an FDA boxed warning for medullary thyroid carcinoma (MTC) risk, though conflicting clinical evidence has generated tremendous controversy regarding this association. METHODS: We analyzed SEER and FAERS databases to compare MTC and papillary thyroid cancer (PTC) reporting proportions (RP) between the general population and GLP-1RA users (n = 109 168), controlling for surveillance bias by comparing against other endocrine and non-endocrine drugs. Negative binomial regression was used to estimate the incidence rate ratios (IRR) in the FAERS dataset among patients with reported AEs. RESULTS: The 10-year mean MTC RP in SEER/FAERS was 0.0002%/0.0014%, while PTC was 0.012%/0.0087%. Strikingly, GLP-1RA users showed increased RPs as compared to the total FAERS RPs: MTC 0.071% (50.7-fold increase) and PTC 0.164% (18.9-fold increase) with significantly elevated IRRs (p = 0.0001) compared to reference groups. CONCLUSION: GLP-1RAs showed a higher RP for MTC compared to other drug classes, warranting prospective studies to investigate further. |
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| ジャーナル名 | Head & neck |
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| Pubmed追加日 | 2026/4/20 |
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| 投稿者 | D'Arcy, Stella J; Kennedy, Sophia L; Thomas, Jerin A; Rahman, Husneara; Sison, Cristina; Kamdar, Dev; Periera, Lucio; Miles, Brett; Frank, Douglas; Seetharamu, Nagashree; Taneja, Charit; Mandal, Rajarsi |
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| 組織名 | Northwell, New Hyde Park, New York, USA.;Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York,;USA.;Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New;York, USA.;Biostatistics Unit, Office of Academic Affairs, New Hyde Park, New York, USA.;Department of Otolaryngology, Long Island Jewish Medical Center, New Hyde Park,;New York, USA.;Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, New |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42003032/ |
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