| アブストラクト | The purpose of this study was to determine the relationship between triptans (sumatriptan, rizatriptan, and zolmitriptan) and cardiovascular (CV) adverse events with data from the FDA Adverse Event Reporting System (FAERS). FAERS database was used to collect data on triptans from 1997 to 2023. Disproportionality methods were utilized to quantify triptan-associated CV events and to identify the potential risk. The reporting odds ratio was used to identify the risk signals. CV outcomes related to age, sex, clinical results, and other factors were also examined for triptans; 820 reports involving the triptans were recognized as CV adverse events out of total of 12 699 reports that were gathered from on FAERS database. Women reported more CV adverse events with rizatriptan and zolmitriptan as compared to men. The CV adverse event risk was highest among individuals aged 18-64. Clinical outcome analysis showed that sumatriptan carries a higher CV risk than rizatriptan and zolmitriptan, and most deaths and serious cases have been documented for sumatriptan. The patients prescribed sumatriptan or zolmitriptan were at a higher risk of reporting CV events for chest pain and chest discomfort, compared to rizatriptan. This finding may provide support for the clinical observation and risk evaluation of triptan treatment. |
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| ジャーナル名 | Canadian journal of physiology and pharmacology |
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| Pubmed追加日 | 2024/10/22 |
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| 投稿者 | Sharma, Priyanka; Varghese Gupta, Sheeba; Bhatt, Priyanka; Kandukuru, Abhishek; Cheng, Feng; Upadhyay, Gunjan; Sutariya, Vijaykumar |
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| 組織名 | Department of Pharmaceutical Sciences, Taneja College of Pharmacy, University of;South Florida, Tampa, FL 33612, USA. RINGGOLD: 7831;Department of Pharmaceutical Sciences, Wegmans School of Pharmacy, St. John;Fisher University, Rochester, NY 14618, USA. RINGGOLD: 6926;SGN Nanopharma, Inc., Tampa, FL, USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39435747/ |
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