| アブストラクト | RATIONALE: COPD and obstructive sleep apnoea (OSA) are both independently associated with an increased risk of cardiovascular disease. It is not clear whether this risk is further increased in COPD-OSA overlap. We aimed to determine whether COPD-OSA overlap has a higher cardiovascular burden compared with COPD or OSA alone. METHODS: This was a matched cohort study using electronic health records from the Clinical Practice Research Datalink Aurum database (England). Exposures of interest were a diagnosis of COPD, OSA or both based on validated code lists. Our primary outcome of interest was cardiovascular mortality defined using ICD-10 codes. Our secondary outcomes of interest included: all-cause mortality, incident acute coronary syndrome (ACS), incident stroke and incident heart failure. RESULTS: The initial study cohort consisted of 365 667 people with COPD (mean+/-sd) age 68+/-11 years, 59 526 with OSA age 57+/-11 years and 11 040 with COPD-OSA age 65+/-10 years. Cardiovascular mortality was significantly higher in patients with COPD-OSA overlap compared with OSA alone (adjusted hazard ratio 1.72 (1.58-1.88); p<0.001) but not compared with COPD alone. People with COPD-OSA overlap had 27% and 58% increased risk of developing ACS compared with COPD and OSA alone respectively, and 69% and 101% increased risk of developing heart failure compared with COPD and OSA respectively. CONCLUSIONS: We have demonstrated that people with COPD-OSA overlap have a significantly higher cardiovascular burden compared with COPD or OSA alone with real-world implications. Earlier and targeted treatment with cardiovascular optimisation can potentially reduce downstream sequelae. |
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| ジャーナル名 | ERJ open research |
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| Pubmed追加日 | 2026/10/27 |
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| 投稿者 | Shah, Amar J; Qummer Ul Arfeen, Muhammad; Denaxas, Spiros; Fitzpatrick, Natalie; Murphy, Patrick; Hurst, John R; Mandal, Swapna |
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| 組織名 | UCL Respiratory, University College London, London, UK.;Royal Free Hospital NHS Foundation Trust, London, UK.;Institute of Health Informatics, University College London, London, UK.;British Heart Foundation Data Science Center, Health Data Research UK, London,;UK.;IT:U, Linz, Austria.;Guys' and St Thomas' Hospital NHS Foundation Trust, London, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42936569/ |
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