| アブストラクト | Depression diagnoses have surged recently, and selective serotonin reuptake inhibitors (SSRIs) are the go-to treatment. However, studies indicate that long-term use of SSRIs can increase cardiovascular risk without systematic evaluation of the drug class. To offer clinical guidance, we performed an evaluation of the association between the six most commonly prescribed SSRIs and cardiovascular adverse events. Using the FDA Adverse Event Reporting System (FAERS) from Q1 2004 to Q2 2022, we conducted a disproportionality analysis and determined the magnitude of significant signals using statistical shrinkage transformations. Our study revealed that arrhythmias, torsades de pointes/QT prolongation, cardiomyopathy, and hypertension were among the most prevalent adverse events linked to SSRIs. Our analysis also showed a significant association between SSRIs and the aforementioned adverse events, with higher incidence in middle-aged and elderly patients and women. We further observed a rising trend in the incidence of arrhythmias, torsades de pointes/QT prolongation, and hypertension, highlighting the need for heightened cardiac monitoring in patients on SSRIs. |
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| ジャーナル名 | Psychiatry research |
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| 投稿日 | 2023/6/27 |
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| 投稿者 | Chen, Yukun; Fan, Qingze; Liu, Yang; Shi, Yue; Luo, Hongli |
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| 組織名 | Department of Pharmacy, the Affiliated Hospital of Southwest Medical University,;Luzhou, Sichuan, China; School of Pharmacy, Southwest Medical University, Luzhou,;Sichuan, China.;Luzhou, Sichuan, China.;Luzhou, Sichuan, China. Electronic address: lyfylhl@163.com. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37364503/ |
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