| アブストラクト | Ado-trastuzumab emtansine (T-DM1) is an antibody-drug conjugate consisting of the monoclonal antibody trastuzumab linked to the maytansinoid DM1 with potential antineoplastic activity and is approved for human epidermal growth factor receptor 2 (HER2)-positive breast cancer. An analysis of the US Food and Drug Administration (FDA) Adverse Event Reporting System identified 124/1,243 (10%) renal adverse events for trastuzumab. However, there are no published case reports describing kidney biopsy findings related to nephrotoxicity of either trastuzumab or T-DM1. We report kidney biopsy findings in a case of nephrotic range proteinuria due to collapsing focal segmental glomerulosclerosis (FSGS) and tubular injury after initiation of T-DM1 therapy. After systematic exclusion of other causes, it is likely that the observed collapsing FSGS was associated with the prior initiation of T-DM1 therapy. This is further supported by the clinical course with improvement of proteinuria and kidney function 3 weeks after discontinuation of T-DM1 therapy without further specific treatment. In summary, we provide the first report of kidney biopsy findings in a case of nephrotic range proteinuria after initiation of T-DM1 therapy due to collapsing FSGS. This issue is especially relevant since T-DM1 is widely used, and nephrologists have to be aware of this potentially rare but severe complication. |
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| ジャーナル名 | Frontiers in oncology |
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| Pubmed追加日 | 2021/12/17 |
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| 投稿者 | Hakroush, Samy; Wulf, Svenja; Gallwas, Julia; Tampe, Bjorn |
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| 組織名 | Institute of Pathology, University Medical Center Gottingen, Gottingen, Germany.;Department of Gynecology and Obstetrics, University Medical Center Gottingen,;Gottingen, Germany.;Department of Nephrology and Rheumatology, University Medical Center Gottingen, |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/34912725/ |
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