| アブストラクト | BACKGROUND: Pharmacokinetics and pharmacodynamics of drugs in elderly individuals differ from those in younger adults; thus, adverse drug events (ADEs) are common in older patients with polypharmacy because co-existing comorbidities elevate the risk of ADEs occurring. However, ADEs have not yet been characterised based on the elderly patients of Japanese origin and polypharmacy. OBJECTIVE: The 100 most commonly reported ADEs were grouped into four classes (Class 1-Class 4) based on elderly patients with polypharmacy. PATIENTS AND METHODS: In this study, logistic regression analysis was performed using cases recorded in the Japanese Adverse Drug Event Report (JADER) database. RESULTS: ADEs in elderly patients treated with polypharmacy-in whom the risk of electrolyte abnormalities, renal and respiratory disorders, and coagulopathy was high-were categorised as 'Class 1 [E(+), P(+)]', while ADEs in elderly patients not treated with polypharmacy-in whom the risk of delirium and fall was high-were categorised as 'Class 2 [E(+), P(-)]'. When there was no association with being elderly, ADEs associated with polypharmacy that carried a high risk of myelosuppression and infection were categorised as 'Class 3 [E(-), P(+)]', and allergic ADEs that were not affected by being elderly or polypharmacy, were categorised as 'Class 4 [E(-), P(-)]'. Class 1 events as well as Class 3 ADEs occurred more frequently in females than in males, whereas Class 3 ADEs (deep vein thrombosis and pulmonary embolism) occurred more frequently in males. CONCLUSIONS: Class 1 and Class 2 ADEs should be investigated in analyses that focus on individual drugs. |
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| ジャーナル名 | Drugs - real world outcomes |
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| Pubmed追加日 | 2020/12/29 |
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| 投稿者 | Negishi, Akio; Oshima, Shinji; Horii, Norimitsu; Mutoh, Mizue; Inoue, Naoko; Numajiri, Sachihiko; Ohshima, Shigeru; Kobayashi, Daisuke |
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| 組織名 | Laboratory of Analytical Pharmaceutics and Informatics, Faculty of Pharmacy and;Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama,;350-0295, Japan.;350-0295, Japan. soshima@josai.ac.jp.;Laboratory of Pharmacy Management, Faculty of Pharmacy and Pharmaceutical;Sciences, Josai University, Saitama, Japan.;Josai University Pharmacy, Saitama, Japan.;Student Learning Assistance Centre, Faculty of Pharmacy and Pharmaceutical |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/33367976/ |
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