| アブストラクト | OBJECTIVES: We aimed to describe patient characteristics, healthcare utilization, and in-hospital mortality among patients with COVID-19 in Japan across waves. METHODS: Using a large-scale hospital-based database, we identified patients hospitalized for COVID-19 in the first (January-June 2020), second (June-October 2020), third (October 2020-February 2021), fourth (March-June 2021), and fifth (June-December 2021) waves. We summarized patient characteristics, healthcare utilization, and in-hospital mortality during each wave and performed multivariable logistic regression analyses for in-hospital mortality. RESULTS: From the first to fifth waves, the number of patients (mean age +/- standard deviation, years) was 2958 (61.2 +/- 22.8), 7981 (55.6 +/- 25.3), 18,788 (63.6 +/- 22.9), 17,729 (60.6 +/- 22.6), and 23,656 (51.2 +/- 22.3), respectively. There were 190 (6.4%), 363 (4.5%), 1261 (6.7%), 1081 (6.1%), and 762 (3.2%) in-hospital deaths, respectively. The adjusted odds ratios for in-hospital deaths (95% confidence interval) were 0.78 (0.65-0.95), 0.94 (0.79-1.12), 0.99 (0.84-1.18), 0.77 (0.65-0.92), in the second to fifth waves, respectively, compared with the first wave. CONCLUSIONS: In-hospital COVID-19 mortality improved from the first to the second wave; however, during the third and fourth waves, mortality was as serious as in the first wave. Although in-hospital mortality during the fifth wave improved, careful monitoring is needed for upcoming waves, considering changing patient and viral characteristics. |
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| ジャーナル名 | Heliyon |
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| 投稿日 | 2023/10/9 |
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| 投稿者 | Suzuki, Toshiki; Taniguchi, Yuta; Komiyama, Jun; Kuno, Toshiki; Adomi, Motohiko; Abe, Toshikazu; Inokuchi, Ryota; Miyawaki, Atsushi; Imai, Shinobu; Saito, Makoto; Ohbe, Hiroyuki; Aso, Shotaro; Kamio, Tadashi; Tamiya, Nanako; Iwagami, Masao |
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| 組織名 | School of Medicine, University of Tsukuba, Tsukuba, Japan.;Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba,;Japan.;Health Services Research and Development Center, University of Tsukuba, Tsukuba,;Department of Health Services Research, Faculty of Medicine, University of;Tsukuba, Tsukuba, Japan.;Department of Cardiology, Montefiore Medical Center, Albert Einstein Medical;College, NY, USA.;Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston,;MA, USA.;Department of Emergency and Critical Care Medicine, Tsukuba Memorial Hospital,;Tsukuba, Japan.;Department of Public Health, Graduate School of Medicine, The University of,;Tokyo, Tokyo, Japan.;Division of Pharmacoepidemiology, Department of Healthcare and Regulatory;Sciences, Showa University School of Pharmacy, Tokyo, Japan.;Division of Infectious Diseases, Advanced Clinical Research Center, The Institute;of Medical Science, The University of Tokyo, Tokyo, Japan.;Department of Clinical Epidemiology and Health Economics, School of Public;Health, The University of Tokyo, Tokyo, Japan.;Department of Real World Evidence, Graduate School of Medicine, The University of;Division of Critical Care, Shonan Kamakura General Hospital, Kamakura, Kanagawa,;Faculty of Epidemiology and Population Health, London School of Hygiene and;Tropical Medicine, London, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37809807/ |
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