| アブストラクト | AIMS: This retrospective, longitudinal study characterised 2430 adults (mean age 40.8+/-16.1years) with newly diagnosed type 1 diabetes (T1D) over the first 5years of insulin treatment. METHODS: Data from 1year pre- and up to 5 years post-insulin initiation were extracted from the UK Clinical Practice Research Datalink (1990-2013). Baseline HbA(1c), BMI and Charlson comorbidity index (CCI) score were compared with data at 1, 2, 3 and 5 years. RESULTS: Mean HbA(1c) decreased significantly from baseline 95+/-32.8mmol/mol (10.8+/-3.0%) to 61+/-21.9mmol/mol (7.7+/-2.0%) at 1year, remaining significantly lower at 2, 3 and 5 years (p<0.0001). One year after initiating insulin, only 6.3% of patients had HbA(1c) <48mmol/mol (<6.5%). There was no further improvement in HbA1c after 1year. Mean BMI increased significantly from baseline 25.3+/-5.5kg/m(2) to 27.2+/-5.8kg/m(2) at 1year; p<0.0001), remaining significantly higher thereafter, with over two-thirds having overweight/obesity by year 5. Mean CCI score increased significantly (1.32, baseline; 1.46, year 1; 1.75, year 5). CCI patterns were similar within BMI and HbA(1c) strata. CONCLUSIONS: More intensive support to reach and maintain glycaemic targets soon post-diagnosis, while avoiding weight gain, and prevention and optimal management of comorbidities are warranted. |
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| ジャーナル名 | Primary care diabetes |
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| 投稿日 | 2019/11/2 |
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| 投稿者 | Ramtoola, Shenaz; Nyeland, Martin Erik; Jacobsen, Judith; Ploug, Uffe Jon; Kragh, Nana; Zimmermann, Esther |
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| 組織名 | Department of Diabetes, Royal Blackburn Hospital, Blackburn, United Kingdom.;Electronic address: Shenaz.Ramtoola@elht.nhs.uk.;Novo Nordisk A/S, Copenhagen, Denmark.;Statcon ApS, Kokkedal, Denmark. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/31668975/ |
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