| アブストラクト | It has been suggested that chronic eczematous eruptions of the elderly could be associated with chronic drug exposure. To determine the drugs associated with these eruptions, we conducted a case-control study on 102 cases and 204 controls. Cases were consecutive patients older than 60 years presenting with an eczematous eruption that had evolved continuously or recurrently for more than 3 months without a reliable cause. Two controls were matched to each case on age, sex, in/outpatient origin, and center. Information about drug exposure was obtained from patients and their pharmacists. Drug use for more than 3 months within the year preceding the eruption was compared between cases and controls. An association was found between calcium channel blockers (CCB) and eczema, with a matched OR (odds ratio) of 2.5 (95% CI (confidence interval): 1.3-4.6). To ascertain the course of patients after CCB withdrawal, two ancillary studies were performed on 74 patients with eczematous eruptions from our department before the case-control study period, and on 101 patients registered in the French "Pharmacovigilance" database. Healing of these eruptions after CCB withdrawal occurred in 83 and 68% of these cases, respectively. The long-term use of CCB is a risk factor for chronic eczematous eruptions of the elderly. |
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| ジャーナル名 | The Journal of investigative dermatology |
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| 投稿日 | 2007/8/24 |
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| 投稿者 | Joly, Pascal; Benoit-Corven, Cloe; Baricault, Sophie; Lambert, Audrey; Hellot, Marie F; Josset, Veronique; Barbaud, Annick; Courville, Philippe; Delaporte, Emmanuel; Collet, Evelyne; Carvalho, Priscille; Modeste-Duval, Anne B; Lacour, Jean P; L'Anthoen-Arditi, Marie H; Thuillez, Christian; Benichou, Jacques |
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| 組織名 | Department of Dermatology, Inserm U519, Rouen University Hospital, Rouen, France.;Pascal.Joly@chu-rouen.fr |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/17713574/ |
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