| アブストラクト | OBJECTIVE: Despite the high prevalence of chronic low back pain (CLBP) and osteoarthritis (OA), few estimates of the economic cost of these conditions in England have been published. The aim of the present analysis was to characterise the economic burden of moderate-to-severe pain associated with CLBP + OA and CLBP alone compared with general population-matched controls without CLBP or OA. The primary objective was to describe the total healthcare resource use (HCRU) and direct healthcare costs associated with the target patient populations. Secondary objectives were to describe treatment patterns and surgical procedures. METHODS: This was a retrospective, observational cohort study of patients receiving healthcare indicative of moderate-to-severe chronic pain associated with CLBP, with or without OA. We used linked longitudinal data from the Clinical Practice Research Datalink GOLD and Hospital Episode Statistics (HES). Patients (cases) were matched 1 : 1 with controls on age, sex, comorbidity burden, GP practice, and HES data availability. RESULTS: The CLBP-alone cohort comprised 13 554 cases with CLBP and 13 554 matched controls; the CLBP + OA cohort comprised 7803 cases with both OA and CLBP and 7803 matched controls. Across all follow-up periods, patients with CLBP alone and those with CLBP + OA had significantly more GP consultations, outpatient attendances, emergency department visits, and inpatient stays than controls (all p < 0.0001). By 36 months after indexing, the mean (SD) per-patient total direct healthcare cost in the CLBP-alone cohort was pound5081 ( pound5905) for cases and pound1809 ( pound4451) for controls (p < 0.0001); in the CLBP + OA cohort, the mean (SD) per-patient total direct healthcare cost was pound8819 ( pound7143) for cases and pound2428 ( pound4280) for controls (p < 0.0001). CONCLUSION: Moderate-to-severe chronic pain associated with CLBP-with or without OA-has a substantial impact on patients and healthcare providers, leading to higher HCRU and costs versus controls among people with CLBP alone or together with OA. |
|---|
| ジャーナル名 | International journal of clinical practice |
|---|
| Pubmed追加日 | 2023/11/29 |
|---|
| 投稿者 | Coates, Greg; Clewes, Peter; Lohan, Christoph; Stevenson, Hannah; Wood, Robert; Tritton, Theo; Knaggs, Roger D; Dickson, Alastair J; Walsh, David A |
|---|
| 組織名 | Pfizer UK, Tadworth, UK.;Pfizer Australia, Sydney, New South Wales, Australia.;Adelphi Real World, Bollington, UK.;Pain Centre Versus Arthritis and NIHR Nottingham Biomedical Research Centre,;School of Medicine, University of Nottingham, Nottingham, UK.;Primary Care Rheumatology & Musculoskeletal Medicine Society, York, UK.;The North of England Low Back Pain Pathway, NIHR Applied Research Collaboration;(ARC) North East and North Cumbria, St. Nicholas' Hospital, Newcastle Upon Tyne,;UK.;AD Outcomes Ltd., York, UK. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38020538/ |
|---|
