| アブストラクト | BACKGROUND: The optimal strategy for modern chemotherapy should be based on a comprehensive approach for cancer patients with cardiovascular diseases. Therefore, cardio-oncology has received increasing attention owing to the cardiotoxic effects of anti-cancer therapies. OBJECTIVES: We aimed to evaluate the clinical characteristics and outcomes of patients with heart failure (HF) who received chemotherapy compared with those of a matched cohort with HF who did not receive chemotherapy, using real-world HF data. METHODS: This study was based on the Diagnosis Procedure Combination (DPC) database of the Japanese Registry of All Cardiac and Vascular Diseases (JROAD). We identified 1 328 113 patients who were hospitalized for HF between April 2012 and March 2021. The propensity score (PS) was estimated using a logistic regression model, with chemotherapy as the dependent variable, and a clinically score-matched analysis of 11 532 patients with HF with or without chemotherapy. The primary endpoint was readmission. RESULTS: Colon, lung, breast and prostate cancers accounted for >60% of all cancer types. After PS matching, readmission was significantly more frequently observed in patients with chemotherapy than those without [odds ratio (OR), 1.26; 95% confidence interval (CI) 1.17-1.36, P < 0.01]. In particular, treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) (OR, 1.69; 95% CI 1.39-2.07), taxane (OR, 2.95; 95% CI 2.11-4.12), anthracyclines (OR, 1.86; 95% CI 1.19-2.90) and fluorouracil agents (OR, 1.65; 95% CI 1.18-2.30) caused a higher risk of readmission. CONCLUSIONS: Medical providers need to monitor and follow-up patients with HF, depending on the characteristics of the anti-cancer agents and types of cancer. |
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| ジャーナル名 | ESC heart failure |
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| Pubmed追加日 | 2025/1/13 |
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| 投稿者 | Sunaga, Tomiko; Okada, Takahiro; Iso, Yoshitaka; Ebato, Mio; Toshida, Tsutomu; Nawata, Shuichi; Suzuki, Hiroshi; Kogo, Mari |
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| 組織名 | Department of Hospital Pharmaceutics, School of Pharmacy, Showa University,;Tokyo, Japan.;Division of Applied Pharmaceutical Education and Research, Hoshi University,;Department of Pharmacy, Showa University Hospital, Tokyo, Japan.;Division of Cardiology, Department of Internal Medicine, Showa University;Fujigaoka Hospital, Yokohama, Japan.;Department of Pharmacy, Showa University Northern Yokohama Hospital, Yokohama,;Japan.;Division of Pharmacotherapeutics, Department of Clinical Pharmacy, School of;Pharmacy, Showa University, Tokyo, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39801274/ |
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