| アブストラクト | BACKGROUND: The literature has paid very little attention to pericarditis, pericardial effusion and pancreatitis during clozapine treatment in children and adolescents. METHODS: Cases of clozapine-associated pericarditis and pancreatitis in children were studied using searches in: 1) PubMed (June 16, 2023), and 2) the World Health Organization's pharmacovigilance database (June 1, 2022), VigiBase. VigiBase uses a logarithmic measure of disproportionality called the information component (IC). RESULTS: The PubMed search yielded 3 clozapine-associated pericarditis cases, 1 pancreatitis case and 1 with both. VigiBase provided a significant clozapine-associated pericarditis IC = 3.6 with an IC(025) = 2.9 (only 3 cases were expected while 22 were observed). VigiBase provided a significant clozapine-associated pancreatitis IC = 2.2 with an IC(025) = 1.4 (only 3 cases were expected while 16 were observed). In VigiBase clozapine-associated pericarditis and pericardial effusion in youth looked similar and on a continuum with myocarditis, as myocarditis, pericarditis and pancreatitis appeared to occur mainly during clozapine titration. Combining PubMed and VigiBase we identified: 1) 29 cases of at least possible clozapine-associated pericarditis/pericardial effusion (6 probable and 23 possible) including 7 cases with and 22 without myocarditis, and 2) 17 cases of clozapine-associated pancreatitis (1 definite and 16 possible). Two of the pancreatitis cases occurred during overdoses. No fatal outcomes were found in any clozapine-associated pericarditis and pancreatitis cases. CONCLUSIONS: Despite the lack of attention in the literature to clozapine-associated pericarditis and pancreatitis, results demonstrate that they can happen in youth, particularly during titration. Pericarditis and pancreatitis appear to be forms of clozapine-associated inflammation during dose titration. |
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| 組織名 | Psychiatry Unit, Department of Health Sciences, University Magna Graecia of;Catanzaro, Catanzaro, Italy. Electronic address: rdefilippis@unicz.it.;Department of Internal Medicine, Dermatology and Psychiatry, School of Medicine,;University of La Laguna, Canary Islands, Spain; Instituto Universitario de;Neurociencia (IUNE), Universidad de La Laguna, San Cristobal de La Laguna, Spain.;Department of Physical Medicine and Pharmacology, School of Medicine, Universidad;de La Laguna, Canary Islands, Spain; Hospital Universitario de Canarias,;Tenerife, Spain.;Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital,;University of Zurich, Zurich, Switzerland; Department of Psychiatry Research,;Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York, USA.;Department of Psychiatry Research, Zucker Hillside Hospital, Northwell Health,;Glen Oaks, New York, USA; Department of Psychiatry and Molecular Medicine, The;Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY,;USA; Department of Child and Adolescent Psychiatry, Charite Universitatsmedizin,;Berlin, Germany. Electronic address: CCorrell@northwell.edu.;Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA;;Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol;Hospital, University of the Basque Country, Vitoria, Spain. Electronic address:;jdeleon@uky.edu. |
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