| アブストラクト | INTRODUCTION: Clozapine-induced myocarditis in children (age </=18 yo) was studied from a PubMed search (18 July 2022) (9 cases) and from the World Health Organization's pharmacovigilance database, called Vigibase, of adverse drug reaction (ADR) reports (72 non-duplicated cases). VigiBase uses a logarithmic measure of disproportionality called the information component (IC). A logistic regression model of presence/absence (40/32) of seriousness in VigiBase was developed. AREAS COVERED: VigiBase provided a significant myocarditis IC = 4.2 with an IC(025) = 3.8; only 4 clozapine-induced myocarditis cases were expected, while 72 were observed. The PubMed search identified 9 cases, while VigiBase identified 72 cases (of which 67 did not overlap with published cases). These 76 combined cases included 35 doubtful (most with missing information on the day of diagnosis), 19 possible and 22 probable, according to the ADR scale. After adjusting for confounders, quetiapine increased the risk of seriousness with an odds ratio (OR) of 17.6 (95% confidence interval CI, 1.56 to 198.6), while Australian origin decreased it with an OR = 0.13 (CI, 0.04 to 0.47). EXPERT OPINION: These 41 cases of at least possible clozapine-induced myocarditis indicated that this ADR can definitively occur in children, particularly in the first 30 days of up-titration. Children's and adult cases appeared similar. |
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| 組織名 | Department of Internal Medicine, Dermatology and Psychiatry, School of Medicine;and Instituto Universitario de Neurociencia (IUNE) University of La Laguna,;Canary Islands, Spain.;Department of Psychiatry, Complejo Hospitalario Universitario de Santiago,;Santiago de Compostela, Spain.;Laboratory of Clinical Psychopharmacology, Beijing Key Laboratory of Mental;Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.;The National Clinical Research Centre for Mental Disorders & Beijing Key Lab of;Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing,;China.;Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital,;University of Zurich, Zurich, Switzerland.;The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks,;New York, USA.;Department of Physical Medicine and Pharmacology, School of Medicine, Universidad;de La Laguna, Canary Islands, Spain.;Hospital Universitario de Canarias, Tenerife, Spain.;Mental Health Research Center at Eastern State Hospital, Lexington, KY, US.;Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol;Hospital, University of the Basque Country, Vitoria, Spain. |
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