| アブストラクト | BACKGROUND: The choice of prophylactic antibiotics for use in endonasal transsphenoidal surgery (ETSS) lacks universal standards. This study aimed to investigate the effectiveness of cefazolin, ampicillin and third-generation cephalosporins for preventing postoperative meningitis and secondary outcomes (in-hospital death and the combination of pneumonia and urinary tract infection) in patients who have undergone ETSS. METHODS: The study used data from the Diagnosis Procedure Combination database in Japan. Data from 10 688 patients who underwent ETSS between April 2016 and March 2021 were included. Matching weight analysis based on propensity scores was conducted to compare the outcomes of patients receiving cefazolin, ampicillin or third-generation cephalosporins as prophylactic antibiotics. RESULTS: Of the 10 688 patients, 9013, 102 and 1573 received cefazolin, ampicillin and third-generation cephalosporins, respectively. The incidence of postoperative meningitis did not significantly differ between the cefazolin group and the ampicillin group (OR, 1.02; 95% CI, 0.14-7.43) or third-generation cephalosporins group (OR, 0.81; 95% CI, 0.10-6.44). Similarly, in-hospital death and the composite incidence of pneumonia and urinary tract infection did not differ between the cefazolin group and the ampicillin or third-generation cephalosporins group. CONCLUSIONS: Cefazolin, ampicillin and third-generation cephalosporins as perioperative prophylactic antibiotics for ETSS do not differ significantly in terms of preventing meningitis. |
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| ジャーナル名 | The Journal of antimicrobial chemotherapy |
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| 投稿日 | 2023/10/19 |
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| 投稿者 | Hattori, Yujiro; Tahara, Shigeyuki; Aso, Shotaro; Makito, Kanako; Matsui, Hiroki; Fushimi, Kiyohide; Yasunaga, Hideo; Morita, Akio |
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| 組織名 | Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical;School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan.;Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon;Medical School, Tokyo, Japan.;Department of Real World Evidence, Graduate School of Medicine, The University of;Tokyo, Tokyo, Japan.;Department of Biostatistics and Bioinformatics, Graduate School of Medicine, The;University of Tokyo, Tokyo, Japan.;Department of Health Policy and Informatics, Tokyo Medical and Dental University;Graduate School of Medicine, Tokyo, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37856687/ |
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