| アブストラクト | AIM: To evaluate the renal prognosis of dipeptidyl peptidase-4 inhibitor (DPP-4i) users and non-users using real-world Asian data. METHODS: Using databases from DeSC Healthcare, Inc., patients aged 30 years or older who used antidiabetic drugs from 2014 to 2021 were identified. Propensity score matching analyses were used to compare renal prognosis between DPP-4i users and non-users. The primary outcomes were estimated glomerular filtration rate (eGFR) decline and end-stage kidney disease (ESKD) development in the eGFR of 45 mL/min/1.73m(2) or higher and eGFR of less than 45 mL/min/1.73m(2) groups, respectively. RESULTS: In total, 65 375 and 9866 patients were identified in the eGFR of 45 mL/min/1.73m(2) or higher and eGFR of less than 45 mL/min/1.73m(2) groups, respectively. In the eGFR of 45 mL/min/1.73m(2) or higher group, propensity score matching created 16 002 pairs. A significant difference was observed in the primary outcome of eGFR decline between DPP-4i users and non-users at 2 years (-2.31 vs. -2.56 mL/min/1.73m(2): difference, 0.25 mL/min/1.73m(2); 95% confidence interval [CI], 0.06-0.44) and 3 years (-2.75 vs. -3.41 mL/min/1.73m(2): difference, 0.66 mL/min/1.73m(2); 95% CI, 0.39-0.93). In the eGFR less than 45 mL/min/1.73m(2) group, propensity score matching created 2086 pairs. After a mean of 2.2 years of observation, ESKD development was 1.15% and 2.30% in users and non-users, respectively, and Kaplan-Meier analysis revealed a significant difference (log rank P = .005). CONCLUSIONS: This retrospective real-world study revealed that patients using DPP-4is had a better renal prognosis than those not using DPP-4is. |
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| ジャーナル名 | Diabetes, obesity & metabolism |
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| 投稿日 | 2024/8/1 |
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| 投稿者 | Hashimoto, Hideaki; Satoh, Michihiro; Nakayama, Shingo; Toyama, Maya; Murakami, Takahisa; Obara, Taku; Nakaya, Naoki; Mori, Takefumi; Hozawa, Atushi; Metoki, Hirohito |
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| 組織名 | Division of Nephrology and Endocrinology, Faculty of Medicine, Tohoku Medical and;Pharmaceutical University, Sendai, Japan.;Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku;Medical and Pharmaceutical University, Sendai, Japan.;Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank;Organization, Tohoku University, Sendai, Japan.;Department of Pharmacy, Tohoku Medical and Pharmaceutical University Hospital,;Sendai, Japan.;Department of Nephrology, Self-Defense Forces Sendai Hospital, Sendai, Japan.;Division of Aging and Geriatric Dentistry, Department of Rehabilitation;Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.;Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan.;Tohoku Institute for Management of Blood Pressure, Sendai, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39086031/ |
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