| アブストラクト | OBJECTIVES: This study compared the effectiveness of first-time use of faster aspart with rapid-acting insulin analogues in patients with type 1 diabetes (T1D) or type 2 diabetes (T2D). DESIGN, SETTING: This retrospective cohort study used data from 1 January 2017 to 8 May 2021 captured in the Clinical Practice Research Datalink Aurum database in the UK. INTERVENTIONS: Patients with T1D or T2D either initiating faster aspart or another rapid-acting insulin analogue ('new users') or switching from a rapid-acting insulin analogue to faster aspart or to another rapid-acting insulin analogue ('switchers') were included. The index date was the date of first prescription of faster aspart or a rapid-acting insulin analogue, or of switching to a different rapid-acting analogue or to faster aspart. PARTICIPANTS: A total of 9695 and 2170 patients were included in the new users (T1D, 1737; T2D, 7958) and switchers cohorts (T1D, 1764; T2D, 406), respectively. PRIMARY AND SECONDARY OUTCOME MEASURES: Glycated haemoglobin (HbA1c) change at 6 months, occurrence of hypoglycaemia from index to 12 months post-index and treatment persistency from index to discontinuation or censoring. RESULTS: Numerically greater reductions were observed with faster aspart than rapid-acting insulins in T1D switchers and new users in change in HbA1c at 6 months. Patients with T1D who switched to faster aspart experienced a significant reduction in rate of hypoglycaemia (p=0.0021). Treatment persistency was higher with faster aspart than with rapid-acting insulins among T1D switchers. No distinction in treatment persistency was observed between the treatment groups for T1D new users or T2D switchers. CONCLUSIONS: Reductions in HbA1c were numerically larger with faster aspart in three of four subgroups. There was higher treatment persistency with faster aspart vs rapid-acting insulin analogues among T1D switchers. TRIAL REGISTRATION NUMBER: NN1218-4967. |
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| ジャーナル名 | BMJ open |
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| Pubmed追加日 | 2025/10/30 |
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| 投稿者 | Davies, Melanie J; Alibegovic, Amra Ciric; Jensen, Anders Boeck; Kelkar, Pranav; Nordsborg, Rikke Baastrup; Thamattoor, Usha K; Braae, Uffe Christian |
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| 組織名 | Diabetes Research Centre, Leicester General Hospital, Leicester, UK;melanie.davies@uhl-tr.nhs.uk.;NIHR Leicester Biomedical Research Centre, Leicester General Hospital, Leicester,;UK.;Novo Nordisk A/S, Soborg, Denmark.;Novo Nordisk, Bengaluru, Karnataka, India. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41161851/ |
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