Comparison of zonisamide with non-levodopa, anti-Parkinson’s disease drugs in the incidence of Parkinson’s disease-relevant symptoms.
INTRODUCTION: Patients with Parkinson's disease (PD) experience various symptoms, both from the disease progression itself and the medication. Few large-scale studies have investigated the associations between zonisamide and these symptoms. This study compared zonisamide and other anti-PD drugs by analyzing their associations with the incidence of PD-relevant symptoms.
METHODS: This was a cohort study based on claims data from Diagnosis Procedure Combination hospitals between 2008 and 2014 in Japan. Patients were included in the cohort if they were diagnosed with PD, aged >/=40years, and were prescribed anti-PD drugs from the same single class without switching to/combination use with other classes excepting levodopa. The outcomes were the incidence of PD-relevant symptoms from the following categories; mental/psychiatric, autonomic nervous system, motor-related, and gastric symptoms. The associations between the incidence of these symptoms and the prescriptions of 8 different classes of anti-PD drugs were explored by the survival analysis.
RESULTS: In the final cohort, 9157 patients were included. The zonisamide use was significantly associated with a lower risk of dementia, insomnia, and gastric ulcers than 3 of 7 other classes without levodopa (p<.05).
CONCLUSION: There may be a potential clinical impact of zonisamide on some of the PD-relevant symptoms.
|ジャーナル名||Journal of the neurological sciences|
|投稿者||Iwaki, Hirotaka; Tagawa, Masaaki; Iwasaki, Kosuke; Kawakami, Koji; Nomoto, Masahiro|
|組織名||Department of Neurology and Clinical Pharmacology, Ehime University Graduate;School of Medicine, 454 Shitsukawa, Toon, Ehime 791-0295, Japan. Electronic;address: firstname.lastname@example.org.;Medical Affairs, Sumitomo Dainippon Pharma Co., Ltd., 13-1 Kyobashi 1-Chome,;Chuo-ku, Tokyo 104-8356, Japan. Electronic address:;email@example.com.;Milliman Inc., 1-6-2 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan. Electronic;address: firstname.lastname@example.org.;Department of Pharmacoepidemiology, Graduate School of Medicine and Public;Health, Kyoto University, Yoshida Konoecho, Sakyo-ku, Kyoto 606-8501, Japan.;Electronic address: email@example.com.;address: firstname.lastname@example.org.|