| アブストラクト | INTRODUCTION: Confusion is an adverse drug reaction frequently observed with valproic acid. Some case reports are published in the literature but no systematic study from a sample of patients has been published. We performed this study in order to describe the main characteristics of this adverse drug reaction. METHODS: Using the French Pharmacovigilance database, we selected the cases of confusion reported since 1985 with valproic acid. RESULTS: 272 cases of confusion were reported with valproic acid: 153 women and 119 men. Confusion mostly occurred during the two first weeks following valproic acid exposure (39.7%). It was "serious" for almost 2/3 of the patients (62.5%) and its outcome favourable in most of the cases (82%). The occurrence of this ADR was more frequent in patients aged between 61 and 80 years. CONCLUSION: This work shows that confusion with valproic acid is a serious, rather frequent but reversible adverse drug reaction. It occurs especially in older patients and during the first two weeks of treatment. |
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| ジャーナル名 | Pharmacopsychiatry |
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| 投稿日 | 2009/3/25 |
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| 投稿者 | Bondon-Guitton, E; Sommet, A; Montastruc, J L |
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| 組織名 | Unite de Pharmacoepidemiologie, Universite de Toulouse, Faculte de Medecine, and;Service de Pharmacologie Clinique, Centre Midi-Pyrenees de Pharmcovigilance,;Centre Hospitalier Universitaire de Toulouse, France. guitton@cict.fr |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/19308880/ |
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