| アブストラクト | AIM: Postpartum depression is a mood disorder that commonly affects women during the early postpartum period. The objective of this study was to analyse the association of postpartum depression with drugs (including contraceptive devices and implants) with spontaneously reported adverse events reported in the US Food and Drug Administration Adverse Event Reporting System database. DESIGN: Retrospective study. METHOD: Reports of postpartum depression events between 2004-2015 were analysed with a reporting odds ratio (ROR) algorithm. The Medical Dictionary for Regulatory Activities was used to identify postpartum depression. RESULTS: The reporting odds ratios (95% confidence intervals, CI) of levonorgestrel (an intrauterine device with progestogen), etonogestrel (a hormonal contraceptive implant), sertraline and drospirenone (an oral contraceptive) were 12.5 (8.7-18.0), 14.0 (8.5-22.8), 12.2 (6.5-23.1) and 5.4 (2.7-10.9) respectively. Among the drugs in the US Food and Drug Administration Adverse Event Reporting System database, the use of contraceptives or an intrauterine device with progestogen might convey risk for postpartum depression. |
|---|
| ジャーナル名 | Nursing open |
|---|
| Pubmed追加日 | 2018/3/31 |
|---|
| 投稿者 | Horibe, Megumi; Hane, Yuuki; Abe, Junko; Matsui, Toshinobu; Kato, Yamato; Ueda, Natsumi; Sasaoka, Sayaka; Motooka, Yumi; Hatahira, Haruna; Hasegawa, Shiori; Kinosada, Yasutomi; Hara, Hideaki; Nakamura, Mitsuhiro |
|---|
| 組織名 | Department of Nursing School of Health Sciences Asahi University Gifu Japan.;Molecular Pharmacology Department of Biofunctional Evaluation Gifu Pharmaceutical;University Gifu Japan.;Laboratory of Drug InformaticsGifu Pharmaceutical University Gifu Japan.;Medical Database Co., LTD Tokyo Japan.;Present address: Department of Environmental Affairs and Citizen Support Gifu;Prefectural Government Gifu Japan.;Present address: Division of Pharmacy Ehime University Hospital Shitsukawa, Toon;Ehime Japan.;United Graduate School of Drug Discovery and Medical Information Sciences Gifu;University Graduate School of Medicine Gifu Japan. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/29599988/ |
|---|
