| アブストラクト | AIMS: As the glucose tolerance of patients with diabetes worsens, autonomic nervous system (ANS) function decreases. Only a few studies, using plasma glucose, have reported on this relationship in large general populations that include people with wide range of glycemia. This study aimed to examine correlates of ANS function with special reference to HbA(1c) which is more stable than plasma glucose among community residents. METHODS: Spectral analysis was performed to assess heart rate variability (HRV) using 1-minute electrocardiogram RR interval data recordings from 7690 residents aged 35-79 years in Nagahama City, Japan. HRV parameters were log-transformed. Multiple regression analysis was performed using potential correlates. RESULTS: lnLF decreased with age (regression coefficient, -0.025; P < 0.001), BMI (-0.010; P = 0.035), and HbA(1c) (-0.068; P = 0.036). lnHF decreased with age (-0.029; P < 0.001), BMI (-0.032; P < 0.001), and HbA(1c) (-0.173; P < 0.001). lnLF/HF increased with age (0.003; P = 0.002), BMI (0.023; P < 0.001), and HbA(1c) (0.105; P < 0.001). Women showed lower lnLF and lnLF/HF than men. Sleep quality assessed by the Pittsburgh Sleep Quality Index, smoking and drinking had almost no relation. CONCLUSIONS: Although the associations were weak, age, BMI and HbA(1c) were inversely correlated with parasympathetic activity, while positively correlated with sympathetic activity among general residents. |
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| ジャーナル名 | Diabetes research and clinical practice |
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| 投稿日 | 2020/4/4 |
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| 投稿者 | Takahashi, Naomi; Takahashi, Yoshimitsu; Tabara, Yasuharu; Matsumoto, Takeshi; Kawaguchi, Takahisa; Kuriyama, Akira; Ueshima, Kenji; Matsuda, Fumihiko; Chin, Kazuo; Nakayama, Takeo |
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| 組織名 | Department of Health Informatics, School of Public Health, Kyoto University,;Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:;ntakahashi@kuhp.kyoto-u.ac.jp.;y-takahashi@umin.ac.jp.;Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, 53;Shogoinkawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address:;tabara@genome.med.kyoto-u.ac.jp.;Department of Respiratory Medicine, Graduate School of Medicine, Kyoto;University, 54 Shogoinkawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. Electronic;address: mtakeshi@kuhp.kyoto-u.ac.jp.;tkawa@genome.med.kyoto-u.ac.jp.;akira.kuriyama.jpn@gmail.com.;Department of EBM Research, Institute for Advancement of Clinical and;Translational Science, Kyoto University Hospital, 54 Shogoinkawahara-cho,;Sakyo-ku, Kyoto 606-8507, Japan. Electronic address:;ueshima.kenji.5m@kyoto-u.ac.jp.;fumi@genome.med.kyoto-u.ac.jp.;Department of Respiratory Care and Sleep Control Medicine, Graduate School of;Medicine, Kyoto University, 54 Shogoinkawahara-cho, Sakyo-ku, Kyoto 606-8507,;Japan. Electronic address: chink@kuhp.kyoto-u.ac.jp.;nakayama.takeo.4a@kyoto-u.ac.jp. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/32243903/ |
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