| アブストラクト | The association between COVID-19 vaccines and vasovagal malaise (VVM) has recently been reported in the literature. Our study aimed to describe COVID-19 vaccines associated VVM cases and to identify risk factors of COVID-19 vaccines associated VVM. To this end, we performed a descriptive study of VVM reports associated with COVID-19 vaccines from two French mass COVID-19 vaccination centers. We also extracted reports of VVM associated with all-COVID-19 vaccines in VigiBase(R), the World Health Organization (WHO) pharmacovigilance database to analyze demographic data. In the two French mass vaccination center database, 408 entries reported VVM after the standard administration of tozinameran - Pfizer(R) (1.63/1,000 vaccinated persons). Of these cases, 213 (52.2%) occurred in women, and 193 (47.3%) occurred in the 18-29 year-old (yo) age group. In 232 cases (56.8%), patients had a history of anxiety related to needles or medical visits, 213 (52.2%) reported a fear of COVID-19 vaccination in particular, and 233 (57.1%) had a history of VVM. In VigiBase(R), 336,291 notifications of COVID-19 vaccines associated with VVM were identified in the adult population during the period of analysis. The most reported age class was 18-44 years (52.4%), and women represented 71.7% of the reports. Reporting widely differed depending on the country. This study, performed in real-life conditions, highlights that VVM is associated with all-COVID-19 vaccines. Young age and history of anxiety related in young adults could be a triggering factor of vaccines-associated VVM. Further studies are needed to confirm our results. |
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| ジャーナル名 | Human vaccines & immunotherapeutics |
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| Pubmed追加日 | 2022/11/11 |
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| 投稿者 | Chretien, Basile; Stroiazzo, Rheda; Troussier, Leila; Le Houssel, Pierre-Yves; Jacquet, Magali; Lheureux, Cecile; Voyen, Sandy; Court, Philippe; Dolladille, Charles; Alexandre, Joachim; Fedrizzi, Sophie; Humbert, Xavier |
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| 組織名 | Normandie Universite, UNICAEN, Centre regional de pharmacovigilance Normandie;Caen, Caen, France.;Departement de medecine generale, Normandie Universite, UNICAEN, Caen, France.;Centre de vaccination Caen Canada, Caen, France.;Service Departemental d'Incendie et de Secours du Calvados, Centre de vaccination;Parc des Expositions, Caen, France.;Agence regionale de Sante de Normandie, Caen, France.;Prefecture du Calvados, Caen, France.;Normandie Univ, UNICAEN, INSERM U1086, ANTICIPE, Caen, France. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36352760/ |
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