[Cutaneous pigmentation related to intravenous iron extravasation: Analysis from the French pharmacovigilance database].
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アブストラクト INTRODUCTION:Intravenous iron infusion may be complicated by extravasation and lead to cutaneous pigmentation.METHODS:We queried the French pharmacovigilance database to assess the spontaneously reported cases over the 2000-2016 period.RESULTS:Fifty-one cases of cutaneous pigmentation related to intravenous iron extravasation were retrieved, none was associated to necrosis. Most of patients were women aged 20 to 49 years old. The pigmentation was mostly a brown coloration, persisting over one month in 19 cases (37.2%) and over 6 months in 9 cases (17.6%). The management of extravasation and pigmentation was heterogeneous and was rarely followed by a decrease of the coloration.CONCLUSION:Cutaneous pigmentation after intravenous iron extravasation can persist over time and create an aesthetic prejudice, particularly in young women. Standardized extravasation and iron-induced pigmentation management procedures appear necessary.ジャーナル名 Therapie 投稿日 2017/12/10 投稿者 Hermitte-Gandoliere, Alexia; Petitpain, Nadine; Lepelley, Marion; Thomas, Laure; Le Beller, Christine; Astoul, Jacqueline Ponte; Gillet, Pierre 組織名 Service de pharmacie, hopital de Mercy, CHR de Metz-Thionville, 57085 Metz,;France.;Centre regional de pharmacovigilance de Nancy, CHRU de Nancy, 54035 Nancy,;France. Electronic address: n.petitpain@chru-nancy.fr.;Centre regional de pharmacovigilance de Grenoble, CHU de Grenoble, 38043;Grenoble, France.;Centre regional de pharmacovigilance, CHU Henri-Mondor, 94010 Creteil, France.;Centre regional de pharmacovigilance, hopital europeen Georges-Pompidou, 75015;Paris, France.;Centre regional de pharmacovigilance de Marseille, CHU de Marseille, 13009;Marseille, France. Pubmed リンク https://www.ncbi.nlm.nih.gov/pubmed/29221863/ -
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