| アブストラクト | Recent trials have highlighted the cardiotoxicity of ribociclib, a CDK4/6 inhibitor, particularly its association with QT prolongation. However, studies on the link between CDK4/6 inhibitors and cardiotoxic events show inconsistent results, and the factors influencing these events and related drug interactions remain underexplored. To address these uncertainties, our study utilizes the FDA adverse event reporting system database (Q1 2015 to Q1 2024) to examine the cardiotoxic events of CDK4/6 inhibitors in breast cancer patients. We employed a comprehensive analytical framework, applying disproportionality methods including Bayesian confidence propagation neural network, proportional reporting ratio, and reporting odds ratio. Our findings highlight significant variability in cardiotoxic events among different CDK4/6 inhibitors, with ribociclib (IC: 0.26, 95%CI: 0.18-0.34) exhibiting pronounced cardiotoxicity. Notably, ribociclib was associated with serious cardiotoxic events such as torsade de pointes/QT prolongation (IC: 2.11, 95% CI: 1.90-2.29) and conduction defects (IC: 2.07, 95% CI: 1.87-2.23). For the first time, palbociclib has been identified with positive signals for cardiotoxic events at the preferred terms level, including pulmonary oedema, increased blood pressure, myocardial infarction, and cardiac flutter. Moreover, multivariable logistic regression and Bayesian network analyses reveal that age, geographic location, and the number of concomitant medications significantly influence cardiotoxic events. Our study also highlights significant drug interactions that increase the probability of specific cardiotoxic outcomes, notably with drugs like sertraline, lansoprazole, capecitabine, and torasemide. These findings highlight the need for personalized treatment plans to mitigate cardiotoxic events and improve patient safety. |
|---|
| ジャーナル名 | International journal of cancer |
|---|
| Pubmed追加日 | 2024/11/14 |
|---|
| 投稿者 | Li, Ting; Zhang, Miaomiao; Zhang, Tian; Li, Shaoqiang; Kou, Chen; Zhao, Ming; Huang, Jing; Cao, Weihang; Jin, Pengfei |
|---|
| 組織名 | Department of Pharmacy, Beijing Hospital, National Center of Gerontology,;Beijing, China.;Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing,;China.;Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual;Application, Beijing Hospital, Beijing, China.;Department of Pharmacy, China-Japan Friendship Hospital, Beijing, China.;Department of Pharmacy Administration and Clinical Pharmacy, School of;Pharmaceutical Sciences, Peking University, Beijing, China. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39538367/ |
|---|
