| アブストラクト | This study was to examine the recent trends in upper gastrointestinal bleeding in Japan using a large-scale real-world database. The incidence of upper gastrointestinal bleeding was evaluated in the Japan Medical Data Center claims database of 13,019,713 patients aged 20 to 74 years with traceability for 3 months from 2009 to 2014. The incidence was compared with peptic ulcers and gastroesophageal reflux disease. The prescription of medications was also evaluated. The incidence of bleeding was 0.137%, 0.121%, 0.113%, 0.106%, 0.099%, and 0.105% during 2009 to 2014 with a time-dependent decline (p<0.001). Peptic ulcers (>10 times higher than the incidence of bleeding) decreased with time (p<0.001), whereas gastroesophageal reflux disease increased (p = 0.006). Upper gastrointestinal bleeding was higher in male patients and older patients (60-74 years old) (p<0.001 respectively). The prescription rate of antithrombotic medications and proton pump inhibitors increased from 2009 to 2014 (p<0.001 respectively). The incidence of upper gastrointestinal bleeding decreased from 2009 to 2014 in this relatively large-scale real-world database in Japan, concomitant with the decrease in peptic ulcers. The decreased incidence might have been due to changes in the disease structure and therapeutic strategies over time. |
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| ジャーナル名 | Journal of clinical biochemistry and nutrition |
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| 投稿日 | 2021/2/5 |
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| 投稿者 | Fujimoto, Shun; Tsuruoka, Nanae; Esaki, Motohiro; Takamori, Ayako; Sakata, Yasuhisa; Shimoda, Ryo; Akutagawa, Takashi; Node, Koichi; Anzai, Keizo; Sugisaki, Nobuyuki; Iwakiri, Ryuichi; Takagi, Kuniaki; Yamanouchi, Kohei; Fujimoto, Kazuma |
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| 組織名 | Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1;Nabeshima, Saga 849-8501, Japan.;Division of Clinical Research Center, Saga University Hospital, 5-1-1 Nabeshima,;Saga 849-8501, Japan.;EA Pharma Co., Ltd., 1-1, Irifune 2-chome, Chuo-ku, Tokyo 104-0042, Japan.;Takeda Pharmaceutical Company, Ltd., 1-1, Nihonbashimotomachi 2-chome, Chuo-ku,;Tokyo 103-8668, Japan.;Divison of Gastroenterology, Faculty of Medicine, International University of;Health and Welfare, 137-1 Enokitsu, Okawa, Fukuoka 831-8501, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/33536718/ |
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