| アブストラクト | BACKGROUND: There is limited evidence to support the current standard recurrent urinary tract infection (rUTI) definition of >/=2 UTIs within 6 months or >/=3 within 12 months. Information about reinfection risk after meeting criteria for rUTI may aid decisions on the value of prophylactic approaches. AIM: To estimate the risk of subsequent UTI associated with different rUTI definitions. DESIGN & SETTING: Electronic health record study using Infections in Oxfordshire Research Database (IORD, 2008-2019) and the Clinical Practice Research Datalink Aurum (CPRD Aurum, 2010-2019). METHOD: We identified community-acquired UTIs, separated by 28 days, in non-pregnant women aged >/=16 years. We created candidate rUTI definitions, varying the time window from 3-9 months, and the number of UTIs required to meet the definition from 2-3 episodes. For each definition, we calculated Kaplan-Meier risk estimates of subsequent UTIs within 6 and 12 months after meeting rUTI criteria. RESULTS: Of eligible women with at least one UTI, 18% (15 617/84 809) in IORD and 20% (334 487/1 703 088) in CPRD Aurum experienced >/=1 rUTI (current definition). The risk of at least two subsequent UTIs within 12 months after meeting the current rUTI definition rose from 17% (IORD) and 16% (CPRD Aurum) to 33% (IORD) and 32% (CPRD Aurum) under a rUTI definition of >/=3 UTIs within 6 months. Risk of subsequent UTI also increased with age. CONCLUSION: Risk estimates of subsequent UTIs after a rUTI vary according to the definition of rUTI adopted. Estimates provided here could support shared decision making around UTI prophylaxis and stratification of populations included in future rUTI research. |
|---|
| ジャーナル名 | BJGP open |
|---|
| Pubmed追加日 | 2026/2/4 |
|---|
| 投稿者 | Vazquez-Montes, Maria Dla; Fanshawe, Thomas R; Smith, Margaret C; Ahmed, Haroon; Stoesser, Nicole; Walker, A Sarah; Butler, Christopher; Hayward, Gail |
|---|
| 組織名 | Nuffield Department of Primary Health Care Sciences, University of Oxford,;Oxford, UK.;Division of Population Medicine, Cardiff University School of Medicine, Cardiff,;UK.;Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital,;National Institute of Health and Care Research (NIHR) Health Protection Research;Unit in Healthcare Associated Infections and Antimicrobial Resistance, University;of Oxford, Oxford, UK.;NIHR Biomedical Research Centre, Oxford, UK.;Oxford, UK gail.hayward@phc.ox.ac.uk. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41633753/ |
|---|
