| アブストラクト | OBJECTIVES: The aim of this study was to evaluate the status of the global standardization of, and prefectural differences in, systemic lupus erythematosus (SLE) treatments in Japan. METHODS: The National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB Japan) was used. A patient with SLE was defined as having a disease with ICD-10 code M321 or M329 between April 2019 and March 2020, for which oral corticosteroids, immunosuppressive agents, or biologic agents were prescribed at least once during a given month. SLE treatments were evaluated by treatment centre type and prefecture. RESULTS: In total, 74,277 patients met the definition of SLE. The SLE prevalence was 60 per 100,000 (range: 47-102 per 100,000 by prefecture). Nationwide, 79.4% of the patients (range: 52.1-93.3% by prefecture) visited a specialized treatment centre (STC); 37.4% (range: 26.4-51.3% by prefecture) received only oral corticosteroids, with fewer of these patients visiting an STC than a non-STC (34.8% and 49.7%, P < .001); and 21.4% (range: 10.7-35.0%) received hydroxychloroquine, with more of these patients visiting an STC than a non-STC (23.0% and 13.5%; P < .001). CONCLUSIONS: The NDB Japan demonstrated the delayed global standardization of, and prefectural disparity in, SLE treatments in Japan. |
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| 投稿者 | Yokogawa, Naoto; Sakai, Ryoko; Matsushita, Masakazu; Shimizu, Masaki; Inoue, Yuzaburo; Inoue, Eisuke; Yamaji, Ken; Mori, Masaaki; Miyamae, Takako |
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| 組織名 | Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo,;Japan.;Department of Public Health and Epidemiology, Meiji Pharmaceutical University,;Tokyo, Japan.;Department of Rheumatology, Tokyo Women's Medical University School of Medicine,;Department of Internal Medicine and Rheumatology, Juntendo University School of;Medicine, Tokyo, Japan.;Department of Pediatrics and Developmental Biology, Graduate School of Medical;and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.;Department of General Medical Science, Graduate School of Medicine, Chiba;University, Chiba, Japan.;Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan.;Showa University Research Administration Center, Showa University, Tokyo, Japan.;Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental;Sciences, Tokyo Medical and Dental University, Tokyo, Japan. |
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