| アブストラクト | INTRODUCTION: Deliberate self-poisoning (DSP) using drugs is the preferred method of suicide at a global level. Its investigation is hampered by limited sample sizes and data reliability. We investigate the role of the US FDA Adverse Event Reporting System (FAERS), a consolidated pharmacovigilance database, in outlining DSP habits and toxidromes. METHODS: We retrieved cases of 'intentional overdose' and 'poisoning deliberate' from the FAERS (January 2004-December 2021). Using descriptive and disproportionality analyses, we estimated temporal trends, potential risk factors, toxidromes, case-fatality rates and lethal doses (LDs) for the most frequently reported drugs. RESULTS: We retrieved 42,103 DSP cases (17% fatal). Most cases were submitted in winter. Reports of DSP involved younger people, psychiatric conditions, and alcohol use, compared with non-DSP, and fatality was higher in men and older patients. Suspected drugs were mainly antidepressants, analgesics, and antipsychotics. Multiple drug intake was recorded in more than 50% of the reports, especially analgesics, psychotropics, and cardiovascular agents. The most frequently reported drugs were paracetamol, promethazine, amlodipine, quetiapine, and metformin. We estimated LD25 for paracetamol (150 g). CONCLUSION: Worldwide coverage of the FAERS complements existing knowledge about DSP and may drive tailored prevention measures to timely address the DSP phenomenon and prevent intentional suicides. |
|---|
| ジャーナル名 | Drug safety |
|---|
| 投稿日 | 2023/1/24 |
|---|
| 投稿者 | Fusaroli, Michele; Pelletti, Guido; Giunchi, Valentina; Pugliese, Chiara; Bartolucci, Mattia; Necibi, Elena Narmine; Raschi, Emanuel; De Ponti, Fabrizio; Pelotti, Susi; Poluzzi, Elisabetta |
|---|
| 組織名 | Pharmacology Unit, Department of Medical and Surgical Sciences, University of;Bologna, Bologna, Italy. michele.fusaroli2@unibo.it.;Legal Medicine Unit, Department of Medical and Surgical Sciences, University of;Bologna, Bologna, Italy.;Department of Statistical Sciences, University of Bologna, Bologna, Italy.;School of Emergency Medicine, Department of Medical and Surgical Sciences,;University of Bologna, Bologna, Italy. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36689131/ |
|---|
