| アブストラクト | INTRODUCTION: Metformin has been suggested as a therapeutic agent for dementia, but the relevant evidence has been partial and inconsistent. METHODS: We established a national cohort of 210,237 type 2 diabetes patients in the UK Clinical Practice Research Datalink. Risks of incident dementia were compared between metformin initiators and those who were not prescribed any anti-diabetes medication during follow-up. RESULTS: Compared with metformin initiators (n = 114,628), patients who received no anti-diabetes medication (n = 95,609) had lower HbA1c and better cardiovascular health at baseline. Both Cox regression and propensity score weighting analysis showed metformin initiators had lower risk of dementia compared to those non-users (adjusted hazard ratio = 0.88 [95% confidence interval: 0.84-0.92] and 0.90 [0.84-0.96]). Patients on long-term metformin treatment had an even lower risk of dementia. DISCUSSION: Metformin may act beyond its glycemic effect and reduce dementia risk to an even lower level than that of patients with milder diabetes and better health profiles. HIGHLIGHTS: Metformin initiators had a significantly lower risk of dementia compared with patients not receiving anti-diabetes medication. Compared with metformin initiators, diabetes patients not receiving pharmacological treatment had better glycemic profiles at baseline and during follow-up. Patients on long-term metformin treatment had an even lower risk of subsequent dementia incidence. Metformin may act beyond its effect on hyperglycemia and has the potential of being repurposed for dementia prevention. |
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| ジャーナル名 | Alzheimer's & dementia : the journal of the Alzheimer's Association |
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| 投稿日 | 2023/7/3 |
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| 投稿者 | Zheng, Bang; Su, Bowen; Ahmadi-Abhari, Sara; Kapogiannis, Dimitrios; Tzoulaki, Ioanna; Riboli, Elio; Middleton, Lefkos |
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| 組織名 | Ageing Epidemiology Research Unit, School of Public Health, Imperial College;London, London, UK.;Department of Non-communicable Disease Epidemiology, London School of Hygiene &;Tropical Medicine, London, UK.;Department of Epidemiology and Biostatistics, School of Public Health, Imperial;College London, London, UK.;Laboratory of Clinical Investigation, Intramural Research Program, National;Institute on Aging, Baltimore, USA.;Public Health Directorate, Imperial College NHS Healthcare Trust, London, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37395154/ |
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