| アブストラクト | Background: The evaluation of stable coronary artery disease (SCAD) has evolved, and contemporary clinical practice guidelines emphasize the importance of in-depth consideration of procedure indications, risk stratification, and results of non-invasive imaging tests. However, little is known about the appropriate selection of imaging modalities for ischemia evaluation and the comparative cost-effectiveness in real-world clinical practice. Methods and Results: The Japanese Comprehensive Health-Economic Assessment for Appropriate Cardiac Imaging Strategy including Outcome and cost-effectiveness in Stable Coronary Artery Disease Study (J-CONCIOUS), a multicenter observational study, was designed to prospectively enroll 2,500 patients with suspected or known SCAD, register clinical information and administrative records, and follow patients for 3 years. Any diagnostic or cardiac imaging modality (including stress tests using electrocardiography, echocardiography, or myocardial perfusion imaging; coronary computed tomographic angiography; and/or invasive coronary angiography with or without fractional flow reserve assessment) is acceptable. Clinical endpoints, such as all-cause mortality, cardiac death, and non-fatal myocardial infarction, will be obtained, along with quality of life assessment using the Seattle Angina Questionnaire. The cost-effectiveness of individual assessment patterns will be quantified by analysis of Diagnosis Procedure Combination (DPC) data, and quality-adjusted life years and the incremental cost-effectiveness ratio will be calculated. Conclusions: J-CONCIOUS is expected to establish a risk-based and cost-effective imaging strategy for the detection and evaluation of functional myocardial ischemia and/or anatomical coronary imaging in Japan. |
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| ジャーナル名 | Circulation reports |
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| 投稿日 | 2021/3/12 |
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| 投稿者 | Nakata, Tomoaki; Takura, Tomoyuki; Yokoi, Hiroyoshi; Nakajima, Kenichi; Kohsaka, Shun; Hashimoto, Akiyoshi; Nakamura, Masato |
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| 組織名 | Cardiology, Hakodate Goryoukaku Hospital Hakodate Japan.;Department of Healthcare Economics and Health Policy, Graduate School of;Medicine, The University of Tokyo Tokyo Japan.;Cardiovascular Center, Fukuoka San-oh Hospital Fukuoka Japan.;Department of Functional Imaging and Artificial Intelligence, Kanazawa University;Kanazawa Japan.;Department of Cardiology, Keio University School of Medicine Tokyo Japan.;Department of Cardiology, Nephrology and Metabolism and Endocrinology, Sapporo;Medical University School of Medicine Sapporo Japan.;Division of Cardiovascular Medicine, Toho University Ohashi Medical Center Tokyo;Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/33693207/ |
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