| アブストラクト | Background: COVID-19 patients with underlying medical conditions are vulnerable to drug-drug interactions (DDI) due to the use of multiple medications. We conducted a discovery-driven data analysis to identify potential DDIs and associated adverse events (AEs) in COVID-19 patients from the FDA Adverse Event Reporting System (FAERS), a source of post-market drug safety. Materials and Methods: We investigated 18,589 COVID-19 AEs reported in the FAERS database between 2020 and 2021. We applied multivariate logistic regression to account for potential confounding factors, including age, gender, and the number of unique drug exposures. The significance of the DDIs was determined using both additive and multiplicative measures of interaction. We compared our findings with the Liverpool database and conducted a Monte Carlo simulation to validate the identified DDIs. Results: Out of 11,337 COVID-19 drug-Co-medication-AE combinations investigated, our methods identified 424 signals statistically significant, covering 176 drug-drug pairs, composed of 13 COVID-19 drugs and 60 co-medications. Out of the 176 drug-drug pairs, 20 were found to exist in the Liverpool database. The empirical p-value obtained based on 1,000 Monte Carlo simulations was less than 0.001. Remdesivir was discovered to interact with the largest number of concomitant drugs (41). Hydroxychloroquine was detected to be associated with most AEs (39). Furthermore, we identified 323 gender- and 254 age-specific DDI signals. Conclusion: The results, particularly those not found in the Liverpool database, suggest a subsequent need for further pharmacoepidemiology and/or pharmacology studies. |
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| ジャーナル名 | Frontiers in pharmacology |
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| Pubmed追加日 | 2022/8/9 |
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| 投稿者 | Jeong, Eugene; Nelson, Scott D; Su, Yu; Malin, Bradley; Li, Lang; Chen, You |
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| 組織名 | Department of Biomedical Informatics, School of Medicine, Vanderbilt University;Medical Center, Nashville, TN, United States.;Department of Computer Science and Engineering, College of Engineering, the Ohio;State University, Columbus, OH, United States.;Department of Biostatistics, School of Medicine, Vanderbilt University Medical;Center, Nashville, TN, United States.;Department of Computer Science, School of Engineering, Vanderbilt University,;Nashville, TN, United States.;Department of Biomedical Informatics, College of Medicine, the Ohio State;University, Columbus, OH, United States. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35935872/ |
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