| アブストラクト | OBJECTIVE: To identify the ethical challenges associated with the development and implementation of new tuberculosis (TB) drugs and diagnostics. METHODS: Twenty-three semi-structured qualitative interviews conducted between December 2015 and September 2016 with programme administrators, healthcare workers, advocates, policymakers, and funders based in the Americas, Europe, and Africa. Interviews were analysed using thematic analysis. RESULTS: Divergent interests and responsibilities, coupled with power imbalances, are a primary source of ethical challenges; the uncertain risk profiles of new drugs present an additional one. Although this challenge can be partially mitigated through stringent pharmacovigilance, respondents highlighted that high-burden countries tend to lack the resources to facilitate safe implementation. Increased advocacy and community engagement are considered an ethical imperative for future TB development and implementation. CONCLUSIONS: This project helps identify some of the ethical challenges of new TB technologies. It demonstrates that investigating ethical challenges through qualitative research is one way to apprehend the difficulty of implementing new TB technologies. Addressing this difficulty will require that those in positions of power reconsider their interests in relation to disempowered communities. POLICY IMPLICATIONS: Efforts to build consensus regarding what values should underpin the global governance of TB research, prevention, and care are essential to facilitate the ethical implementation of new TB technologies. |
|---|
| 組織名 | Centre for Applied Ethics, McGill University Health Centre, 2155 Guy Street, 2nd;floor, Montreal, Quebec, H3H 2R9, Canada.;Leslie Dan Faculty of Pharmacy & Joint Centre for Bioethics, University of;Toronto, 144 College Street, Toronto, Ontario, M5S 3M2, Canada.;Sydney Health Ethics & Marie Bashir Institute for Infectious Diseases and;Biosecurity, Level 1, Medical Foundation Building, The University of Sydney,;Sydney, NSW, 2006, Australia.;Dalla Lana School of Public Health & Joint Centre for Bioethics, University of;Toronto, 155 College Street, Toronto, ON, M5T 1P8, Canada.;Sydney, NSW, 2006, Australia. diego.silva@sydney.edu.au. |
|---|
