Development of predictive genetic tests for improving the safety of new medicines: the utilization of routinely collected electronic health records.

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Development of predictive genetic tests for improving the safety of new medicines: the utilization of routinely collected electronic health records.

Development of predictive genetic tests for improving the safety of new medicines: the utilization of routinely collected electronic health records.

アブストラクト	Serious adverse drug reactions are an important cause of hospitalization and can result in the withdrawal of licensed drugs. Genetic variation has been shown to influence adverse drug reaction susceptibility, and predictive genetic tests have been developed for a limited number of adverse drug reactions. The identification of patients with adverse drug reactions, obtaining samples for genetic analysis and rigorous evaluation of clinical test effectiveness represent significant challenges to predictive genetic test development. Using the example of serious drug-induced liver injury, we illustrate how a database of routinely collected electronic health records (EHRs) could be used to overcome these barriers by facilitating rapid recruitment to genome-wide association studies and supporting efficient randomized controlled trials of predictive genetic test effectiveness.
ジャーナル名	Drug discovery today
Pubmed追加日	2013/11/19
投稿者	Wing, Kevin; Douglas, Ian; Bhaskaran, Krishnan; Klungel, Olaf H; Reynolds, Robert F; Pirmohamed, Munir; Smeeth, Liam; van Staa, Tjeerd P
組織名	Department of Non-communicable Disease Epidemiology, London School of Hygiene and;Tropical Medicine, London, UK. Electronic address: kevin.wing@lshtm.ac.uk.;Tropical Medicine, London, UK.;Department of Pharmacoepidemiology, Utrecht Institute for Pharmaceutical Sciences;(UIPS), Utrecht University, Utrecht, The Netherlands.;Epidemiology, Pfizer, New York, NY, USA.;The Wolfson Centre for Personalised Medicine, Department of Molecular and;Clinical Pharmacology, University of Liverpool, Liverpool, UK.;Tropical Medicine, London, UK; Department of Pharmacoepidemiology, Utrecht;Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The;Netherlands; Clinical Practice Research Datalink (CPRD), Medicines and Healthcare;Products Regulatory Agency, London, UK.
Pubmed リンク	https://www.ncbi.nlm.nih.gov/pubmed/24239729/