| アブストラクト | Even though digoxin causes many side effects, few cases of skin involvement are recorded in the French Pharmacovigilance Database. We report a case of leukocytoclastic vasculitis (LV) very probably due to digoxin. A 91-year-old woman, hospitalized following a fall, presented cardiac decompensation in a context of rapid atrial fibrillation requiring treatment with digoxin. Eight days later, a rash appeared on her back and trunk. It was neither itchy, nor painful and persisted despite local treatment. There were no other clinical anomalies. After a few days, the rash spread with appearance of bullous lesions, ulcerations and a necrosis on lymphedema of the two legs. Among the complementary examinations, skin biopsy revealed LV with necrosis and subepidermal detachment suggested toxic dermal necrolysis, while direct immunofluorescence was negative. The rash resolved progressively once the digoxin was stopped. The pharmacovigilance department recorded that digoxin was the probable cause. The evidence allowed us to conclude that digoxin was the cause. |
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| 組織名 | Centre de convalescence geriatrique de Fontaine, 67, route d'Ahuy, 21210;Fontaine-les-Dijon, France.;Service de medecine interne et maladies systemiques, CHU Dijon bocage central, 2,;boulevard de Lattre-de-Tassigny, 21000 Dijon, France.;Service de medecine interne geriatrie, hopital de Champmaillot CHU, BP 87909, 2,;rue Jules-Violle, 21079 Dijon cedex, France.;Centre regional de pharmacovigilance, CHU Dijon bocage central, pole des;vigilances, 2, boulevard de Lattre-de-Tassigny, 21000 Dijon, France.;rue Jules-Violle, 21079 Dijon cedex, France; Inserm U1093 : cognition, action et;plasticite sensorimotrice (CAPS), universite de Bourgogne Franche-Comte, BP;27877, 21078 Dijon cedex, France. Electronic address:;patrick.manckoundia@chu-dijon.fr. |
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