| アブストラクト | AIMS: To determine whether the use of dipeptidyl peptidase-4 (DPP-4) inhibitors is associated with an increased risk of community-acquired pneumonia. METHODS: The UK Clinical Practice Research Datalink and the Hospital Episodes Statistics database were used to conduct a nested case-control analysis within a cohort of new users of antidiabetic drugs between 2007 and 2012. Incident cases of hospitalization for community-acquired pneumonia were matched with up to 20 controls on age, duration of treated diabetes, calendar year and duration of follow-up. Conditional logistic regression models were used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for hospitalization for community-acquired pneumonia associated with current use of DPP-4 inhibitors compared with current use of two or more oral antidiabetic drugs. RESULTS: The cohort included 49,653 patients, of whom 562 were hospitalized for community-acquired pneumonia during follow-up (incidence rate 5.2/1000 person-years). Compared with current use of two or more oral antidiabetic drugs, current use of DPP-4 inhibitors was not associated with an increased risk of hospitalized community-acquired pneumonia overall (adjusted OR 0.80, 95% CI 0.50-1.29) or according to duration of use (p for trend = 0.57). CONCLUSIONS: The use of DPP-4 inhibitors was not associated with an increased risk of hospitalization for community-acquired pneumonia. Additional research is needed to assess the association between these drugs and other serious infections. |
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| ジャーナル名 | Diabetes, obesity & metabolism |
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| 投稿日 | 2015/1/13 |
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| 投稿者 | Faillie, J-L; Filion, K B; Patenaude, V; Ernst, P; Azoulay, L |
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| 組織名 | Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital,;Montreal, Quebec, Canada; Department of Pharmacoepidemiology, INSERM U1027,;Faculty of Medicine, Paul Sabatier University, Toulouse, France; Department of;Medical Pharmacology and Toxicology, Pharmacovigilance Regional Center, CHRU;Montpellier University Hospital, Montpellier, France. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/25581902/ |
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