Discontinuation and primary care visits in nonvalvular atrial fibrillation patients treated with apixaban or warfarin.
| アブストラクト | AIM: Nonvalvular atrial fibrillation (NVAF) requires long-term anticoagulation treatment, which may necessitate frequent primary care visits. MATERIALS & METHODS: NVAF patients initiating warfarin or apixaban in 2012-2017 were identified from linked primary (Clinical Practice Research Datalink) and secondary care (Hospital Episode Statistics) data. A propensity score matched Cox regression model compared discontinuation risk. Primary care visits were compared via negative binomial regression. RESULTS: A total of 2695 apixaban users were matched to warfarin patients. Discontinuation risk was lower with apixaban than warfarin (hazard ratio: 0.40; 95% CI: 0.35-0.46). Apixaban patients averaged 12.2 annual primary care visits, versus 17.1 for warfarin users (p < 0.001). CONCLUSION: Apixaban was associated with reduced rates of discontinuation and primary care visits compared with warfarin. |
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| ジャーナル名 | Journal of comparative effectiveness research |
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| 投稿日 | 2019/2/9 |
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| 投稿者 | Ramagopalan, Sreeram V; Graham, Sophie; Carroll, Robert; Raluy-Callado, Mireia; Nordstrom, Beth L; Donaldson, Robert; Colby, Chris; Mehmud, Faisal; Alikhan, Raza |
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| 組織名 | Centre for Observational Research & Data Sciences, Bristol-Myers Squibb,;Uxbridge, UB8 1DH, UK.;Evidera, Real-World Evidence, London, W6 8DL, UK.;Evidera, Real-World Evidence, Waltham, MA 02541, USA.;Evidera, Real-World Evidence, San Francisco, CA 94111, USA.;Bristol-Myers Squibb, Uxbridge, UB8 1DH, UK.;Department of Haematology, University Hospital of Wales, Cardiff, CF14 4XW, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/30734571/ |
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