Discontinuation and primary care visits in nonvalvular atrial fibrillation patients treated with apixaban or warfarin.
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アブストラクト AIM:Nonvalvular atrial fibrillation (NVAF) requires long-term anticoagulation treatment, which may necessitate frequent primary care visits. MATERIALS & METHODS: NVAF patients initiating warfarin or apixaban in 2012-2017 were identified from linked primary (Clinical Practice Research Datalink) and secondary care (Hospital Episode Statistics) data. A propensity score matched Cox regression model compared discontinuation risk. Primary care visits were compared via negative binomial regression.RESULTS:A total of 2695 apixaban users were matched to warfarin patients. Discontinuation risk was lower with apixaban than warfarin (hazard ratio: 0.40; 95% CI: 0.35-0.46). Apixaban patients averaged 12.2 annual primary care visits, versus 17.1 for warfarin users (p < 0.001).CONCLUSION:Apixaban was associated with reduced rates of discontinuation and primary care visits compared with warfarin.ジャーナル名 Journal of comparative effectiveness research 投稿日 2019/2/9 投稿者 Ramagopalan, Sreeram V; Graham, Sophie; Carroll, Robert; Raluy-Callado, Mireia; Nordstrom, Beth L; Donaldson, Robert; Colby, Chris; Mehmud, Faisal; Alikhan, Raza 組織名 Centre for Observational Research & Data Sciences, Bristol-Myers Squibb,;Uxbridge, UB8 1DH, UK.;Evidera, Real-World Evidence, London, W6 8DL, UK.;Evidera, Real-World Evidence, Waltham, MA 02541, USA.;Evidera, Real-World Evidence, San Francisco, CA 94111, USA.;Bristol-Myers Squibb, Uxbridge, UB8 1DH, UK.;Department of Haematology, University Hospital of Wales, Cardiff, CF14 4XW, UK. Pubmed リンク https://www.ncbi.nlm.nih.gov/pubmed/30734571/ -
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