| アブストラクト | INTRODUCTION: Age-related differences in Adverse Event (AE) reporting and reported Time to Onset (TTO) during systemic breast cancer treatment remain poorly characterized. METHODS: We analyzed deduplicated reports from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) from January 2004 through December 2024. Reports involving systemic antineoplastic therapy were classified as Young Breast Cancer (YBC; <40 years) or Non-Young Breast Cancer (NYBC; >/=40 years). Analyses included covariate-adjusted logistic regression, 1:1 propensity-score matching, alternative age cutoffs, treatment-context sensitivity analyses, and adjusted bootstrap median regression. Multiplicity was controlled using Bonferroni correction. RESULTS: Among 71,426 reports (YBC, 4,292; NYBC, 67,134), adjusted reporting odds differed for 10 System Organ Classes (SOCs) and 6 Preferred Terms (PTs); four SOC and four PT associations remained after matching. Unadjusted reported TTO was shorter for 5 SOCs and 8 PTs in YBC. After adjustment, only gastrointestinal disorders (-4.23 days; 95% CI, -7.11 to -1.34) and pyrexia (-5.22 days; 95% CI, -8.79 to -1.65) remained significant. Findings varied across age definitions and treatment contexts. DISCUSSION: This is the first study to systematically characterize AE reporting patterns in YBC through an integrated pharmacovigilance framework. Using FAERS data, we compared YBC and NYBC in terms of reported AE timing and adjusted reporting odds across SOC and PT levels. CONCLUSION: Selected AE reporting patterns differed by age, whereas most reported-TTO differences attenuated after adjustment. These exploratory reporting associations do not establish incidence, comparative toxicity, biological onset, or causality and require confirmation in datasets with exposure denominators and detailed treatment information. |
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| ジャーナル名 | Current cancer drug targets |
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| Pubmed追加日 | 2026/10/19 |
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| 投稿者 | Li, Yongxin; Zhu, Zijun; Lu, Jiatong; Li, Yan; Shen, Guoshuang; Zhao, Jiuda |
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| 組織名 | Breast Disease Diagnosis and Treatment Center, Affiliated Hospital of Qinghai;University and Affiliated Cancer Hospital of Qinghai University, Xining, China.;Qinghai Institute of Health Sciences, Xining, China.;Department of Breast Surgery, Peking Union Medical College Hospital, Chinese;Academy of Medical Sciences and Peking Union Medical College, Beijing, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42895148/ |
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