| アブストラクト | INTRODUCTION: Substantial evidence suggests that drospirenone-containing oral contraceptives may cause a higher risk of venous thrombotic events than earlier-generation oral contraceptives. METHODS: To gain insight into recent real-world implications, we conducted an analysis using the US Food and Drug Administration's Adverse Event Reporting System. RESULTS: Venous thrombotic events continue to be reported at a much higher rate with drospirenone-containing oral contraceptives than the general background. The disproportionality has been rising since 2010. The same behavior is not seen with levonorgestrel-containing oral contraceptives. CONCLUSION: Our results are consistent with decreased physician and patient awareness of risks associated with drospirenone-containing oral contraceptives. |
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| ジャーナル名 | Open access journal of contraception |
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| 投稿日 | 2018/5/4 |
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| 投稿者 | Madigan, David; Shin, Jennifer |
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| 組織名 | Department of Statistics, Columbia University, New York, NY, USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/29720882/ |
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