| アブストラクト | BACKGROUND: Acute kidney injury (AKI) is a public health concern. Among the pathological situations leading to AKI, drugs are preventable factors but are still under-notified. We aimed to provide an overview of drug-induced AKI (DIAKI) using pharmacovigilance and medical administrative databases Methods: A query of the PMSI database (French Medical Information System Program) of adult inpatient hospital stays between 1 January 2017 and 31 December 2018 was performed using ICD-10 (International Classification of Diseases 10th revision) codes to identify AKI cases which were reviewed by a nephrologist and a pharmacovigilance expert to identify DIAKI cases. In parallel, DIAKIs notified in the French Pharmacovigilance Database (FPVDB) were collected. A capture-recapture method was performed to estimate the total number of DIAKIs. RESULTS: The estimated total number of DIAKIs was 521 (95%CI 480; 563), representing 20.0% of all AKIs. The notification was at a rate of 12.9% (95%CI 10.0; 15.8). According to the KDIGO classification, 50.2% of the DIAKI cases were stage 1 and 49.8% stage 2 and 3. The mortality rate was 11.1% and 9.6% required hemodialysis. CONCLUSION: This study showed that drugs are involved in a significant proportion of patients developing AKI during a hospital stay and emphasizes the severity of DIAKI cases. |
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| ジャーナル名 | Journal of clinical medicine |
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| 投稿日 | 2021/1/10 |
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| 投稿者 | Rolland, Anne-Lise; Garnier, Anne-Sophie; Meunier, Katy; Drablier, Guillaume; Briet, Marie |
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| 組織名 | Departement d'Information Medicale, Centre Hospitalo-Universitaire d'Angers,;49100 Angers, France.;Service de Nephrologie-Dialysis-Transplantation, Centre Hospitalo-Universitaire;d'Angers, 49100 Angers, France.;Laboratoire MitoVasc, INSERM U1083, CNRS UMR 6015, Universite d'Angers, 49100;Angers, France.;Service de Pharmacologie-Toxicologie et Centre Regional de Pharmacovigilance,;Centre Hospitalo-Universitaire d'Angers, 49100 Angers, France. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/33418844/ |
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