| アブストラクト | Objectives: As fall events and injuries have become a growing public health problem in older patients and the causes of falls are complex, there is an emerging need to identify the risk of drug-induced falls. Methods: To mine and analyze the risk signals of drug-induced falls in older patients to provide evidence for drug safety. The FDA Adverse Event Reporting System was used to collect drug-induced fall events among older patients. Disproportionality analyses of odds ratio (ROR) and proportional reported ratio were performed to detect the adverse effects signal. Results: A total of 208,849 reports (34,840 fall events and 1,898 drugs) were considered. The average age of the included patients was 76.95 +/- 7.60 years, and there were more females (64.47%) than males. A total of 258 drugs with positive signals were detected to be associated with drug-induced fall incidence in older patients. The neurological drugs (104, 44.1%) with the largest number of positive detected signals mainly included antipsychotics, antidepressants, antiparkinsonian drugs, central nervous system drugs, anticonvulsants and hypnotic sedatives. Other systems mainly included the circulatory system (25, 10.6%), digestive system (15, 6.4%), and motor system (12, 5.1%). Conclusion: Many drugs were associated with a high risk of falls in older patients. The drug is one of the critical and preventable factors for fall control, and the risk level of drug-induced falls should be considered to optimize drug therapy in clinical practice. |
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| ジャーナル名 | Frontiers in pharmacology |
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| 投稿日 | 2022/12/17 |
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| 投稿者 | Zhou, Shuang; Jia, Boying; Kong, Jiahe; Zhang, Xiaolin; Lei, Lili; Tao, Zhenhui; Ma, Lingyue; Xiang, Qian; Zhou, Ying; Cui, Yimin |
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| 組織名 | Department of Pharmacy, Peking University First Hospital, Beijing, China.;Department of Pharmacy, The First Hospital of Tsinghua University, Beijing,;China.;China Pharmaceutical University, Basic Medicine and Clinical Pharmacy, Nanjing,;Jiangsu, China.;Department of Geriatrics, Peking University First Hospital, Beijing, China.;Department of Nursing, Peking University First Hospital, Beijing, China.;Institute of Clinical Pharmacology, Peking University, Beijing, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36523498/ |
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