| アブストラクト | Various drugs have been reported to induce myoclonus. However, this adverse event is not well known because of the difficult diagnosis and the lack of pharmaco-epidemiological or controlled studies. As far as we know, there are only case reports. In the literature, antiparkinsonian medications, antipsychotics, antidepressants, anesthetics, opiates and anti-infectious drugs have been reported in the occurrence of myoclonus. In a French pharmacovigilance database study, only 423 reports (0.2%) involved drug-induced myoclonus. The median age of patients was 55 years and 10% of these patients had a concomitant neurological disease. Only 16% of these reports had a strong imputability score (likely). The most frequently involved drugs were anti-infectious (15%), antidepressants (15%), anxiolytics (14%), and opiates agents (12%). Fifty-six percent of these reports were classified as serious adverse event. Concerning outcome, most patients (84%) recovered without sequels. |
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| ジャーナル名 | Neurophysiologie clinique = Clinical neurophysiology |
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| 投稿日 | 2007/3/6 |
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| 投稿者 | Brefel-Courbon, C; Gardette, V; Ory, F; Montastruc, J L |
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| 組織名 | Service de pharmacologie, faculte de medecine, 37, allees Jules-Guesde, 31000;Toulouse, France. brefel@cict.fr |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/17336778/ |
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