| アブストラクト | BACKGROUND: Drug-induced pancreatitis is a rare disease but frequently reported, owing to the vast number of medications. AIM: To summarize potential drugs causing pancreatitis and to speculate on underlying mechanisms. METHODS: We extracted more than 60,000 reports of pancreatitis submitted to the U.S. Food and Drug Administration Adverse Event Reporting System (January 2004 to March 2023). Data on patient age, sex, weight, time to onset, and outcome (death et al.) were collected. Disproportionality analysis was used in data mining to identify associations between drugs and pancreatitis events. Seven databases, commonly used for network pharmacology analysis, were searched to identify potential targets. RESULTS: Of 867 drugs with 3 or more reports, 101 drugs met all criteria using disproportionality analysis and indicated a potential risk of pancreatitis. The risk of 40 drugs had not been previously noted in "UpToDate" database. Patients taking the drugs had a similar sex distribution, were mostly 45-64 years old, and were heavier (median, 88 kg; P < 0.0001). The median time to onset was 199 days (interquartile range, 27-731.5). Ponatinib (16.48%), tigecycline (14.12%) and valproic acid (13.41%) had higher fatality rates. Potential targets related to pancreatitis were identified in 50 of the 101 drugs. CONCLUSION: Clinicians providing the 101 drugs for treatment should stay vigilant to detect pancreatitis early. |
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| ジャーナル名 | Frontiers in pharmacology |
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| Pubmed追加日 | 2025/5/1 |
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| 投稿者 | Xie, Hao; Jiang, Lin; Peng, Junya; Hu, Haoyang; Han, Meifen; Zhao, Bin |
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| 組織名 | Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of;Medical Science and Peking Union Medical College, Beijing, China.;State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical;College Hospital, Chinese Academy of Medical Science and Peking Union Medical;College, Beijing, China.;Department of Internal Medicine, Peking Union Medical College Hospital, Chinese;Academy of Medical Science and Peking Union Medical College, Beijing, China.;Department of General Surgery, Peking Union Medical College Hospital, Chinese;West China School of Pharmacy, Sichuan University, Chengdu, China.;Department of Pharmacy, Shanghai Children's Medical Center, School of Medicine,;Shanghai Jiao Tong University, Shanghai, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40308779/ |
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