| アブストラクト | PURPOSE: Identify the main pharmacological classes inducing pancreatitis using spontaneous reports recorded in the French pharmacovigilance database (FPVD). METHODS: Cases of pancreatitis recorded in FPVD between January 1st 1985 and December 31st 2013 were selected using the 2001 consensus conference criteria of the French High Health Authority. RESULTS: During this period, 2975 observations were selected with 1151 fulfilling criteria of drug-induced pancreatitis (i.e. 0.22% of total notifications in the FPVD). According to ATC classification, the pharmacological classes most frequently found were antiretroviral, analgesic, lipid-lowering, immunosuppressive and insulin secreting drugs. For some drugs (metformin, omeprazole, etc.) pancreatitis was "unlabelled" in the summary of product characteristics. CONCLUSION: This review allows to identify the main drug classes currently involved in spontaneous reporting of pancreatitis in France. |
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| 投稿者 | Chebane, L; Bagheri, H; Hillaire-Buys, D; Geniaux, H; Yahioui, N; Laroche, M-L; Cottin, J; Spreux, A; Mosquet, B; Pecriaux, C; Bellet, F; Lambert, A; Montastruc, J-L |
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| 組織名 | Laboratoire de pharmacologie medicale et clinique, centre de Midi-Pyrenees de;pharmacovigilance, de pharmaco-epidemiologie et d'informations sur le medicament,;equipe de pharmaco-epidemiologie de l'UMR, Inserm U1027, CHU de Toulouse, faculte;de medecine, universite de Toulouse, 37, allees Jules-Guesde, 31000 Toulouse,;France.;France. Electronic address: haleh.bagheri@univ-tlse3.fr.;Centre regional de pharmacovigilance de Montpellier, 34295 Montpellier cedex 5,;Centre regional de pharmacovigilance de Bordeaux, 33076 Bordeaux cedex, France.;Centre regional de pharmacovigilance de Grenoble, 38043 Grenoble cedex, France.;Centre regional de pharmacovigilance de Limoges, 87042 Limoges cedex, France.;Centre regional de pharmacovigilance de Lyon, 69424 Lyon cedex 3, France.;Centre regional de pharmacovigilance de Nice, 06003 Nice cedex 1, France.;Centre regional de pharmacovigilance de Caen, 14033 Caen cedex 9, France.;Centre de pharmacovigilance de Paris Cochin, 75014 Paris, France.;Centre regional de pharmacovigilance de St-Etienne, 42055 Saint-Etienne cedex 02,;Centre regional de pharmacovigilance de Strasbourg, 67091 Strasbourg cedex, |
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