| アブストラクト | Radiation recall reactions are inflammatory reactions confined to previously irradiated tissues, often of drug-induced etiology, particularly with anticancer therapies. Other drugs, in particular COVID-19 vaccines, may also be involved. To describe radiation recall reactions under non-anticancer drugs more precisely, we extracted the cases of radiation recall reactions associated with non-anticancer drugs from WHO pharmacovigilance database VigiBase(R). We performed two analyses from this extraction: a global analysis and an analysis focusing on vaccination-related issues. We extracted 120 cases corresponding to 269 drugs, of which 130 were non-anticancer (22 vaccines). Among the non-anticancer drugs, tozinameran was the most reported treatment (4.46% of cases), followed by levofloxacin (2.97%) and folinic acid (2.60%), dexamethasone (2.23), and ChAdOx1 nCoV-19 vaccine and prednisone (1.86% each). Among vaccines, tozinameran (54.55% of cases) was the most reported, followed by ChAdOx1 nCoV-19 (22.73%), HPV and inactivated influenza vaccine (9.09% each), and elasomeran (4.55%). Our study first describes the occurrence of radiation recall reactions during non-anticancer treatment. It also highlights a potential safety signal with COVID-19 vaccines. |
|---|
| ジャーナル名 | Fundamental & clinical pharmacology |
|---|
| 投稿日 | 2023/1/7 |
|---|
| 投稿者 | Aubin-Beale, Eyrian; Giorgi, Lorene; Beurrier, Mathilde; Granel-Brocard, Florence; Gillet, Pierre; Fresse, Audrey |
|---|
| 組織名 | Laboratoire de Pharmacologie-Toxicologie, Pharmacovigilance & CEIPA, CHRU de;Nancy Brabois, Batiment de Biologie Medicale et de Biopathologie,;Vandoeuvre-les-Nancy, France.;Service de Dermatologie, CHRU DE NANCY Brabois, Batiment des Specialites;Medicales, Vandoeuvre-les-Nancy, France.;Universite de Lorraine, CNRS, IMoPA, Nancy, France. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36607138/ |
|---|
